The True Endogenous Creatinine Clearance

Haugen, Heidi Østbø; Blegen, E

doi:10.3109/00365515309093514

Cited by 72 publications

(12 citation statements)

References 8 publications

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“…This method also avoids the problem of overestimation of glomerular filtration rate by creatinine clearance, which occurs in diabetes because of the presence of pseudocreatinines. 25 …”

Section: Renal Clearance Studiesmentioning

confidence: 99%

Salt blocks the renal benefits of ramipril in diabetic hypertensive rats.

1991

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To establish if the benefit of angiotensin converting enzyme inhibitor therapy in retarding progressive diabetic renal injury is due to a specific intrarenal effect or the systemic hypotensive effect, we studied the effect of long-term ramipril treatment on blood pressure, glomerular filtration rate, and urinary protein excretion in streptozotocin-diabetic spontaneously hypertensive rats. The hypotensive effect of ramipril was prevented by a high salt diet, which did not alter the degree of renal angiotensin converting enzyme inhibition. Three weeks after uninephrectomy and induction of diabetes, rats were allocated to three groups. Groups 1 and 2 were given 1% NaCl, whereas group 3 was given water as drinking solution. One week later, groups 2 and 3 received 0.4 mg/kg/day ramipril in their drinking solution, which was continued over a 2-month period. Ramipril produced a blood pressure fall only in water-drinking rats (group 3) despite a similar reduction in plasma and renal angiotensin converting enzyme activity in groups 2 and 3. Salt-loaded rats had a progressive increase in urinary protein excretion over the duration of study. Ramipril treatment prevented an increase in protein excretion only in animals given water and with a reduced systolic blood pressure. Glomerular nitration rate was similar in all three groups. Ramipril treatment improved animal survival independently of a reduction in blood pressure or an effect on proteinuria. Although it is possible that angiotensin converting enzyme inhibitors have specific intrarenal effects reducing progression of diabetic proteinuria, concomitant control of systemic blood pressure appears to be necessary to demonstrate a benefit. (Hypertension 1991;17:497-503) U ncontrolled systemic hypertension is a wellknown cause of progressive renal injury in both humans and experimental animals. 1Hypertension is commonly associated with diabetic renal disease,'-3 and it has been shown to accelerate the rate of development of diabetic nephropathy both in humans 4 and in streptozotocin-diabetic rats. 13 or in other renal disorders. 1415 However, it is difficult to determine from these studies if the beneficial effect of ACE Received February 9, 1990; accepted in revised form November 29, 1990. inhibitors was due to a specific intrarenal effect of ACE inhibition or due to their systemic hypotensive effect.To evaluate this question further, we examined the effect of long-term administration of the ACE inhibitor ramipril on blood pressure, glomerular filtration rate, and proteinuria in streptozotocin diabetic uninephrectomized spontaneously hypertensive rats (SHR). To prevent the hypotensive effect of ACE inhibition, the rats were maintained on a high salt diet, which is known to oppose the blood pressurelowering action of ACE inhibitors. -17 Methods Study Protocol

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“…This method also avoids the problem of overestimation of glomerular filtration rate by creatinine clearance, which occurs in diabetes because of the presence of pseudocreatinines. 25 …”

Section: Renal Clearance Studiesmentioning

confidence: 99%

Salt blocks the renal benefits of ramipril in diabetic hypertensive rats.

1991

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“…Sims and Krantz (18), however, measured the clearance of "true" creatinine, which has been shown (19,20) to correspond very closely to the inulin clearance, whereas the Brod and Sirota method (13) we used measures the "creatinine chromogen" clearance. Since the latter method gives somewhat higher plasma "creatinine" levels, creatinine clearance values lower than the simultaneously determined inulin clearance would be expected.…”

Section: Resultsmentioning

confidence: 99%

The Renal Clearance of Endogenous Estrogens in Late Pregnancy*

Brown¹,

Saffan²,

Howard³

et al. 1964

J. Clin. Invest.

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“…Protein-free plasma and urine filtrate creatinine contents were determined by Folin's modification [I31 of alkaline picrate color development after elution from Lloyd's reagent [17). Creatinine in urine GAG specimens and creatinine clearance were measured by standard methods [8, 91.…”

Section: Methodsmentioning

confidence: 99%

Ultrastructural, neurological, and glycosaminoglycan abnormalities in Lowe's syndrome

Wisniewski

Kieras

French

et al. 1984

Annals of Neurology

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The oculocerebrorenal syndrome (OCRS), Lowe's syndrome, is an X-linked, recessive disease characterized by mental retardation, congenital corneal abnormalities and cataracts, growth failure, rickets, osseous abnormalities, renal dysfunction with periodic acidosis, hypotonia, and areflexia. Ultrastructural studies of skin biopsy specimens in three individuals with the disorder (aged 17, 9, and 8 years) revealed cytoplasmic, membrane-bound, electron-lucent vacuoles and some electron-dense membranous inclusion bodies in fibroblasts and Schwann cells, as well as axonal degeneration and vascular changes. Computed tomographic scans evidenced brain atrophy. Urinary excretion of glycosaminoglycans (GAG) was four to five times greater than in normal controls. The predominant urinary GAG was a low-sulfated chondroitin-4-sulfate; chondroitin-6-sulfate and heparan sulfate excretion levels were normal. A tenfold increase in urinary GAG excretion was found in one patient with oculocerebrorenal syndrome during periods of behavioral agitation. These findings suggest that the clinical stigmata of oculocerebrorenal syndrome may be related to a defect in GAG metabolism.

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The True Endogenous Creatinine Clearance

Cited by 72 publications

References 8 publications

Salt blocks the renal benefits of ramipril in diabetic hypertensive rats.

Salt blocks the renal benefits of ramipril in diabetic hypertensive rats.

The Renal Clearance of Endogenous Estrogens in Late Pregnancy*

Ultrastructural, neurological, and glycosaminoglycan abnormalities in Lowe's syndrome

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