The true nature of salivary <scp>NGF</scp>

Borelli, Violetta; Trevisan, Elisa; Gammouh, O; Zabucchi, G.

doi:10.1111/odi.12370

Cited by 1 publication

(2 citation statements)

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“…The stress study in Psychosomatic Medicine (1), and all subsequent studies (3)(4)(5)(6), used an immunoassay produced by Promega (NGF E max immunoassay system, Promega Madison, WI, USA), whereby the test method for use with saliva was developed by Salimetrics (3). As explained by Boreli et al (13), only studies that have used the Promega immunoassay reported detectable levels of NGF-β in saliva. This company recently withdrew its assay from the market, and since then, research groups have been unable to detect salivary NGF-β using other commercially available immunoassays or by using other techniques, such as Western blotting (13,14 and references therein).…”

Section: Closing the Border On A New Frontier: The Problem With Salivmentioning

confidence: 96%

“…The answer remains elusive. Some authors have speculated that the antibody in the Promega immunoassay may have been cross-reacting with pro-NGF (13,14). If this were the case, then the results of Laurent et al (1) require a fundamental reinterpretation because the biological effects of pro-NGF are different from its mature counterpart.…”

Section: Closing the Border On A New Frontier: The Problem With Salivmentioning

confidence: 99%

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Closing the Border on a New Frontier

Turner

Bosch

2016

Psychosomatic Medicine

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