The truth on IgD in the ploy of immune surveillance and inflammation

Rigante, Donato

doi:10.1007/s12026-015-8744-z

Cited by 7 publications

(12 citation statements)

References 34 publications

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“…In addition, the methods for IgD determination have varied across studies and have been less standardized than methods for measuring other immunoglobulin classes , probably because IgD concentrations are less frequently required in clinical practice . In normal individuals, dispersion of serum IgD values is higher than those of other immunoglobulins, ranking from undetectable to several hundreds of milligrams per litre . The potential influence of age and gender on IgD concentrations is controversial.…”

Section: Introductionmentioning

confidence: 84%

“…Immunoglobulin D (IgD) was discovered in a patient with myeloma more than 50 years ago and remains as the most enigmatic of immunoglobulin classes . Whereas IgG, IgA, IgM and IgE functions have been well described, IgD function is largely unknown . IgD exists in two forms.…”

Section: Introductionmentioning

confidence: 99%

“…IgD exists in two forms. On the one hand, IgD is coexpressed with IgM on the surface of mature B cells before antigenic stimulus, as a receptor for that antigen , and on the other, free IgD circulates in the blood where it represents <1% of total immunoglobulin content. Serum IgD concentrations are far lower than those of IgG, IgA or IgM, but higher than those of IgE .…”

Section: Introductionmentioning

confidence: 99%

“…Serum IgD concentrations are far lower than those of IgG, IgA or IgM, but higher than those of IgE . Serum IgD can participate in anti‐infectious immunity and immune regulation, as described in recent reviews .…”

Section: Introductionmentioning

confidence: 99%

“…Serum IgD concentrations are less studied than concentrations of other immunoglobulin classes. The levels are elevated in rare IgD myelomas and may also be elevated in a variety of infectious, inflammatory and autoimmune diseases, as well as in some immunodeficiency disorders . Increased serum concentrations of total IgD and IgD specific to allergens have been reported in patients with allergic respiratory diseases, the most common immune‐based disorders in developed countries, although these findings are not consistent across all studies .…”

Section: Introductionmentioning

confidence: 99%

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Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain

et al. 2017

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Immunoglobulin D (IgD) is the least studied of immunoglobulin classes. This study sought to investigate the potential relationship between demographic, metabolic, lifestyle and immunological factors, and serum IgD concentrations in a general adult population. We measured serum IgD concentrations by means of a commercial turbidimetric assay in 413 individuals (median age, 55 years; 45% males), randomly selected from the adult population of a Spanish municipality. Serum IgD concentrations displayed considerable variation in the population, ranging from undetectable (<6.7 mg/l) to 878 mg/l. Serum IgD concentrations were undetectable in 78 cases (18.9%) and >100 mg/l in 39 cases (9.4%). Median IgD was 21.9 mg/l. Serum IgD concentrations were negatively associated with age and positively associated with smoking, after adjustment for potential confounders. Overweight individuals showed lower concentrations of IgD than did normal-weight individuals. Atopy (positivity of skin tests to aeroallergens) was not significantly associated with IgD concentrations, although non-symptomatic atopics showed higher IgD concentrations. No consistent association was observed between serum IgD concentrations and gender, metabolic syndrome, or alcohol consumption. No significant association was found between baseline IgD concentrations and development of either allergic or immune disease after a median 11.4 years of follow-up. In conclusion, serum IgD concentrations in adults show a wide variation in the population and may be influenced by common factors, particularly age and smoking habit. These factors should be taken into account when defining reference ranges for serum IgD concentrations.

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Section: Introductionmentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain

et al. 2017

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The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases

Itoh¹,

Ohshima²

2023

Allergology International

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The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation

Chen

et al. 2017

Acta Pharmacol Sin

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Immunoglobulin IgD might play an important role in autoimmune diseases, but the function of IgD has remained elusive, despite multiple attempts to define its biological function. Fibroblast-like synoviocytes (FLSs) are specialized cells of the synovium that play a key role in the pathogenesis of rheumatoid arthritis (RA). In this study we explored the possible roles of excessive IgD expression on the function of FLSs from RA patients (RA-FLSs). We showed that IgD Fc receptor (IgDR) was constitutively expressed on FLSs, and was significantly elevated in RA-FLSs compared with FLSs prepared from synovial tissues of healthy controls (HC-FLSs). Furthermore, IgDR was mainly detected on the cell surface and in the cytoplasm. We further detected the intrinsic binding affinity of IgD to IgDR on HC-FLSs with an equilibrium dissociation constant (K) of 0.067 nmol/L. Incubation of RA-FLSs with IgD (1-10 μg/mL) for 48 h dose-dependently promoted the expression of IgDR, and stimulated the production of inflammatory cytokines and chemokines, such as IL-1β, IL-6, monocyte chemotactic protein (MCP)-1, TNF-α and receptor activator of nuclear factor-κB ligand (RANKL), thus potentially contributing to IgD-IgDR crosslinking. Moreover, incubation with IgD (0.1-10 μg/mL) for 48 h dose-dependently enhanced viability for both HC-FLSs and RA-FLSs. Our results demonstrate that IgDR is expressed on RA-FLSs and contributes to the activation of FLSs, and suggest that IgD-IgDR is a potential novel immunotherapeutic target for the management of RA.

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The truth on IgD in the ploy of immune surveillance and inflammation

Cited by 7 publications

References 34 publications

Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain

Factors Influencing Serum Concentrations of Immunoglobulin D in the Adult Population: An Observational Study in Spain

The dual aspects of IgD in the development of tolerance and the pathogenesis of allergic diseases

The immunoglobulin D Fc receptor expressed on fibroblast-like synoviocytes from patients with rheumatoid arthritis contributes to the cell activation

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