The tumor therapeutic potential of long non-coding RNA delivery and targeting

Nanotherapeutic approaches for delivery of long non-coding RNAs: an updated review with emphasis on cancer

“…Drug developments related to lncRNAs are limited by unexpected risks and adverse side effects. 107 The delivery aspect of RNA drugs primarily affects their clinical applications: (i) naked RNA molecules are unstable and hydrophilic; (ii) delivery of RNA molecules to target tissues and cells is difficult due to a lack of efficient carriers. 108 The backbone of RNA is terminated with nucleophilic hydroxyl groups, allowing the nucleotide oligomer to be attacked rapidly and cleaved into monomers.…”

“…209,210 Known as "lipoplexes", these "complexes" have a large size and a positively charged membrane, which has demonstrated considerable utility in vitro but may result in rapid clearance from plasma, toxic effects, and immune responses in vivo. 107 DOTAP is frequently used to produce cationic nanosystems that can bind to anionic nucleic acids and convey them to cells. DOTAP is a biodegradable cationic lipid with a chemical ester bond that degrades with time, thereby diminishing its toxicity.…”

“…Therefore, lncRNA-based drugs target lncRNAs to regulate their expression instead of transferring lncRNAs directly. 107 The delivery of lncRNAs, which are essential for gene regulation and cellular processes, is an area of particular interest. Despite this, conveying lncRNAs to target cells and tissues remains difficult due to their low stability and poor membrane permeability.…”

“…209,210 Known as “lipoplexes”, these “complexes” have a large size and a positively charged membrane, which has demonstrated considerable utility in vitro but may result in rapid clearance from plasma, toxic effects, and immune responses in vivo. 107…”

Editorial of Special Column on RNA Therapeutics and Drug Delivery Technologies for Medical Applications

“…Han et al. 11 reviewed the mechanism and mode of action of lncRNAs and discussed the current delivery platforms of lncRNAs. They also summarized studies using lncRNA as a therapeutic target in cancer.…”