The tumour bed effect reflected in the radius of tumour cords

Moore, J. V.

doi:10.1259/0007-1285-58-691-685

Cited by 3 publications

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“…The radiation injury of the vascular system was probably involved in the destruction of the perivascular cords, and thus the increased occurrence of necrosis in the tumour. Similar observations have been made in irradiated murine tumours (10,16,39), and in a human xenograft (27).…”

Section: Discussionsupporting

confidence: 85%

Histological study of the regrowth of a human melanoma xenograft exposed to single dose irradiation

Falkvoll

1990

APMIS

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Falkvoll, K. H. Histological study of the regrowth of a human melanoma xenograft exposed to single dose irradiation. APMIS 98: [758][759][760][761][762][763][764] 1990.The aim of this investigation was to find the location and the histological characteristics of cells that were the source of tumour regrowth after single dose irradiation. A human melanoma xenograft was irradiated with a single dose of 25.0 Gy which gives local tumour control in nearly 50Yo of treated animals. Serial histological sections were made from tumours removed during the first two weeks after irradiation. During the first week the perivascular organization of tumour parenchyma disappeared and the central part of the tumour became necrotic. The occurrence of vascular stasis, thrombosis and endothelial cell changes indicated that radiation injury to the vascular system was involved in the disappearance of the tumour cords. Tumour cells that remained histologically intact were located in subcapsular areas. The incidence of normal mitotic figures increased, and the fraction of abnormal mitoses and the incidence of micronuclei decreased 5 to 7 days before macroscopical regrowth was usually detected. It is concluded that cells which are the source of tumour regrowth were located in the subcapsular areas at the time of irradiation. Radiation injury to the tumour vascular system was an important factor in the necrotization of the tumour centre after treatment.

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Section: Discussionsupporting

confidence: 85%

Histological study of the regrowth of a human melanoma xenograft exposed to single dose irradiation

Falkvoll

1990

APMIS

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Development of an alternative light source to lasers for photodynamic therapy: 2. Comparative in vivo tumour response characteristics

1995

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The Relationship Between Changes in Tumour Volume, Tumour Cell Density and Parenchymal Cord Radius in a Human Melanoma Xenograft Exposed to Single Dose Irradiation

Kh¹

1990

Acta Oncologica

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A human melanoma xenograft, in which the viable tumour tissue formed cylindrical cuffs around blood vessels, was irradiated with single doses of 7.5 Gy and 15.0 Gy respectively. The nuclear density, the frequency of giant cells and the mean parenchymal cord radius were measured and compared to the tumour growth response. After 7.5 Gy, the growth rate was only slightly reduced and there were no significant changes in the nuclear density or the mean parenchymal cord radius. After 15.0 Gy the mean parenchymal cord radius decreased the first week. This coincided with swelling of endothelial cell nuclei and reduced density of functional capillary-like vessels. Although the number of tumour cells declined, the tumour volume increased the first days after irradiation with 15.0 Gy since the cell density was reduced.

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The tumour bed effect reflected in the radius of tumour cords

Cited by 3 publications

References 0 publications

Histological study of the regrowth of a human melanoma xenograft exposed to single dose irradiation

Histological study of the regrowth of a human melanoma xenograft exposed to single dose irradiation

Development of an alternative light source to lasers for photodynamic therapy: 2. Comparative in vivo tumour response characteristics

The Relationship Between Changes in Tumour Volume, Tumour Cell Density and Parenchymal Cord Radius in a Human Melanoma Xenograft Exposed to Single Dose Irradiation

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