The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer

Yoshino, Hirofumi; Chiyomaru, Takeshi; Enokida, Hideki; Kawakami, Kazumori; Tatarano, Shuichi; Nishiyama, Kenryu; Nohata, Nijiro; Seki, Naohiko; Nakagawa, Masayuki

doi:10.1038/bjc.2011.23

Cited by 248 publications

(312 citation statements)

References 38 publications

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“…Interleukin-6 treatment downregulates miR-370 expression, while 5-aza-dC upregulates miR-370 expression. miR-370 was also found downregulated in bladder carcinoma (Yoshino et al, 2011). These findings seem in conflict with the miR-370 in gastric cancers S-S Lo et al results of our study.…”

Section: Discussioncontrasting

confidence: 84%

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

et al. 2011

Oncogene

101

100

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MicroRNAs (miRNAs) are endogenous non-coding RNAs that are known to be involved in the pathogenesis of tumors. Gastric carcinoma (GC) is a common malignancy worldwide. The aim of this study was the identification of the expression signature and functional roles of aberrant miRNAs in GC. Initial screening established a profile of aberrantly expressed miRNAs in tumors. miR-370 was confirmed to be overexpressed in GC tissues. Higher expression of miR-370 in GC tissues was associated with more advanced nodal metastasis and a higher clinical stage compared with controls. In addition, significantly higher level of miR-370 was noted in the plasma of GC patients compared with controls. Patients having more invasive or advanced tumors also exhibited a higher plasma level of miR-370. In vitro assays indicated that exogenous miR-370 expression enhanced the oncogenic potential of GC cells. The AGS-GFPM2 cells with exogenous miR-370 expression also exhibited enhanced abdominal metastatic dissemination in nude mice. Reporter assays confirmed that miR-370 targeted predicted sites in 3 0 UTR of transforming growth factor-b receptor II (TGFb-RII) gene. The exogenous miR-370 expression decreased TGFb-RII expression and the phosphorylation of Smad3 elicited by TGFb1. The TGFb1-mediated repression in cell migration was reverted by exogenous miR-370 expression. A reverse correlation between miR-370 and TGFb-RII expression was noted in GC tissues. This study concludes that miR-370 is a miRNA that is associated with GC progression by downregulating TGFb-RII. The miRNA expression profile described in this study should contribute to future studies on the role of miRNAs in GC.

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Section: Discussioncontrasting

confidence: 84%

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

et al. 2011

Oncogene

101

100

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“…19 Our previous studies indicated that both miRNAs function as tumor suppressors that target multiple oncogenes. 12,20,21 Recent reports also indicated that miR-1 acts as a tumor suppressor in PCa by influencing multiple cancer-related processes and inhibiting cell proliferation and motility. 22 We also reported miR-145 downregulation in many types of human cancers, including PCa, suggesting that miR-145 functions as a tumor suppressor.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, we sequentially identified tumor suppressive miRNAs in several types of cancers, such as head and neck squamous cell carcinoma, 9,10 esophageal squamous cell carcinoma, 11 bladder cancer, 12,13 renal cell carcinoma 14 and PCa 15 and described the molecular pathways they regulate. Our analysis of miRNA-regulated cancer pathways provided novel insights for diagnostic and therapeutic strategies for these cancers.…”

Section: Introductionmentioning

confidence: 99%

Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer

et al. 2012

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microRNAs (miRNAs) have key roles in human tumorigenesis, tumor progression and metastasis. miRNAs are aberrantly expressed in many human cancers and can function as tumor suppressors or oncogenes that target many cancer-related genes. This study seeks to identify novel miRNA-regulated molecular pathways in prostate cancer (PCa). The miRNA expression signature in clinical specimens of PCa showed that 56 miRNAs were significantly downregulated in PCa compared with nonPCa tissues. We focused on the top four downregulated miRNAs (miR-187, miR-205, miR-222 and miR-31) to investigate their functional significance in PCa cells. Expression levels of these four miRNAs were validated in PCa specimens (15 PCa tissues and 17 non-PCa tissues) to confirm that they were significantly reduced in these PCa tissues. Gain-of-function analysis demonstrated that miR-222 and miR-31 inhibited cell proliferation, invasion and migration in PCa cell lines (PC3 and DU145), suggesting that miR-222 and miR-31 may act as tumor suppressors in PCa. Genome-wide gene expression analysis using miR-222 or miR-31 transfectants to identify the pathways they affect showed that many cancer-related genes are regulated by these miRNAs in PC3 cells. Identification and categorization of the molecular pathways regulated by tumor suppressive miRNAs could provide new information about the molecular mechanisms of PCa tumorigenesis.

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“…Recent studies have shown that several miRNAs, such as miR-146a, miR-155, and miR-21, are involved in H. pylori-induced infection (23)(24)(25). MiR-370 has been verified as a tumor suppressor in bladder cancer and cholangiocarcinoma cell lines (26,27). Furthermore, FoxM1 is predicted as a putative target of miR-370 by bioinformatics.…”

Section: Introductionmentioning

confidence: 99%

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

Feng

Wang

Zeng

et al. 2013

Molecular Cancer Research

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Helicobacter pylori (H. pylori) infections are strongly implicated in human gastric mucosa-associated diseases. Forkhead box M1 (FoxM1), a key positive regulator of cell proliferation, is overexpressed in gastric cancer. MicroRNAs are important post-transcriptional regulators of gene expression. In this study, the effects of H. pylori infection on FoxM1 expression and possible mechanisms of carcinogenesis were explored. The expression of FoxM1 was gradually increased in human gastric specimens from inflammation to cancer. FoxM1 upregulation was time-and concentration-dependent in gastric epithelial-derived cell lines infected with H. pylori. CagA, a key virulence factor of H. pylori, was associated with increased FoxM1 expression.

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The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer

Cited by 248 publications

References 38 publications

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

Overexpression of miR-370 and downregulation of its novel target TGFβ-RII contribute to the progression of gastric carcinoma

Tumor suppressive microRNAs (miR-222 and miR-31) regulate molecular pathways based on microRNA expression signature in prostate cancer

FoxM1 is Overexpressed in Helicobacter pylori–Induced Gastric Carcinogenesis and Is Negatively Regulated by miR-370

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