The turn towards prevention – moral narratives and the vascularization of Alzheimer’s disease

Leibing, Annette

doi:10.1080/14636778.2019.1637722

Cited by 8 publications

(3 citation statements)

References 64 publications

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“…Based on pilot studies (27)(28)(29) we detected several emerging ethical and social incongruities affecting the capacity of individuals in their respective environments to recoup the potential of the "new dementia". These include issues around individual responsibility for lifestyle decisions, our relationship with novel monitoring technologies, and the fit between the "new dementia" and existing local cultures of care.…”

Section: Study Hypothesis and Objectivesmentioning

confidence: 99%

Optimizing the Aging Brain: The BEAD Study on the Ethics of Dementia Prevention

Andreoletti

Lazzaroni²,

Petersen³

et al. 2023

J Frailty Aging

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Dementia has lately undergone a profound reconceptualization. Long conceived of as an unpreventable process of mental deterioration, current evidence shows that it can be prevented in at least one in three cases intervening on a specified set of factors. Issues of justice and equity loom large on the implementation of dementia prevention, from a global health perspective. Our project thus embraces emerging evidence about dementia risk factors and their uneven distribution nationally and globally by specifically focusing on the situated aspects of dementia prevention. The aim of the BEAD study (Optimizing the Aging Brain? Situating Ethical Aspects in Dementia Prevention) is to dissect the ethical and clinical assumptions of this novel understanding of dementia, and to analyze how such new discourse on dementia prevention plays out in three countries: Canada, Germany and Switzerland. This study adopts a multi-perspective, comparative, qualitative approach, combining stakeholder interviews with different kinds of focused ethnographies, elaborating on conceptual, ethical, and social aspects of what we would like to call the "new dementia". By situating the paradigmatic shifts in Alzheimer's and dementia research within current aging cultures and contemporary social policies, we aim to initiate a debate about the often implicit unresolved social, ethical, and political implications and preconditions of the medical understanding and handling of cognitive disorders.

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Section: Study Hypothesis and Objectivesmentioning

confidence: 99%

Optimizing the Aging Brain: The BEAD Study on the Ethics of Dementia Prevention

Andreoletti

Lazzaroni²,

Petersen³

et al. 2023

J Frailty Aging

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“…Experts are grappling with the magical thinking of prevention they helped sow, and they are facing backlash against the prevention campaign's having unwittingly promoted further stigmatization of those who have dementia (see Lock ). In the absence of a clear diagnosis, cure, or means of prevention, it seems inevitable that a biomedical declaration or even prediction of dementia remains what Naoko Miyaji has called a “curse” for many (see Kitanaka ; Leibing ).…”

Section: Ambivalence Toward the Neurobiologization Of The Lifecyclementioning

confidence: 99%

In the Mind of Dementia: Neurobiological Empathy, Incommensurability, and the Dementia Tojisha Movement in Japan

Kitanaka

2020

Med Anthropol Q

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Living in the world's leading superaging society, Japanese are confronted with a tsunami of dementia that has generated fear of becoming mentally incommensurable to oneself and to others. Based on three years of fieldwork in various clinical settings, including a memory clinic in Tokyo, I show how people with dementia (dementia tojishas) and doctors have employed three approaches to overcoming incommensurability: psychotherapeutic, neurobiological, and ecological. With a primary focus on the neurobiological, I show how tojishas and doctors try to cultivate what I call "neurobiological empathy," asking people to imagine not just how to be together with those with dementia but also what it is to be (in the mind of someone) with dementia. Investigating both the effects and limits of the neurobiologization of dementia, I ask how the dementia tojisha movement can work toward diminishing the preexisting fear about dementia and supplementing incommensurability with understanding and empathy. [dementia, empathy, incommensurability, neurobiology, Japan]

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“…For example, there are (at least) two possible theories here: a notion that ADAD's are different disease entities, along a spectrum perhaps, but with their own taxonomies; or of a "dementia continuum," a syndrome (Fox et al 2013), that is a "dimensional (lying along a continuum)" rather than a "categorical (representing a distinct entity)" construct (Walter 2010, 534). In addition, for some, the etiology that has come to predominate dementia science is the amyloid or "pathological cascade" hypothesis (Karran, Mercken, and De Strooper 2011) that also indicates ADAD happens over time and starts years before someone can be said to have dementia; while for others, dementia remains deeply correlated with growing old and with, for example, cardio-vascular change, that can be prevented through lifestyle activities (Leibing 2019;Livingston et al 2017). Both constructions of dementia in their different ways have the possibility of shifting dementia from being a problem of old age to a problem of ageing, one that can be known and managed and even eventually treated (Perry, Zhu, and Smith 2013).…”

Section: In Pursuit Of Biomarkersmentioning

confidence: 99%

Biomarkers and brains: situating dementia in the laboratory and in the memory clinic

Latimer

Hillman

2019

New Genetics and Society

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This paper provides a comparison of how genetic biomarkers are used (or not) in three contexts: clinic-based diagnostic work with people; lab-based research on mice and their marbles; and lab-based research on thrashing nematodes. For all the worldwide drive to find biomarkers that can be used in the detection of early, presymptomatic dementia, there is little research on how or when the association between biomarkers and a definitive disease are being made to "hold." First, we show the disjuncture between the animal modeling that underpins laboratory attempts to stabilize genetic biomarkers and the paradigms that inform clinical diagnosis. Secondly, we develop this theme to show how in our third site, an epigenetics "worm" laboratory, neurodegenerative changes are explored as located in specific geneenvironment interactions over time. We speculate whether such an enactment brings us closer to a notion of "situated biology," to undercut possibilities of making genetic biomarkers of preclinical dementia hold.

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The turn towards prevention – moral narratives and the vascularization of Alzheimer’s disease

Cited by 8 publications

References 64 publications

Optimizing the Aging Brain: The BEAD Study on the Ethics of Dementia Prevention

Optimizing the Aging Brain: The BEAD Study on the Ethics of Dementia Prevention

In the Mind of Dementia: Neurobiological Empathy, Incommensurability, and the Dementia Tojisha Movement in Japan

Biomarkers and brains: situating dementia in the laboratory and in the memory clinic

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