The Two Janus Faces of CpRu‐Based Deallylation Catalysts and Their Application for in Cellulo Prodrug Uncaging
Alain Baiyoumy,
Robin Vinck,
Thomas R. Ward
Abstract:In the past 18 years, metal‐catalyzed deallylation has proven a useful tool for studying biological processes in cellulo and in the early development of innovative therapeutic catalytic strategies. This reaction is catalyzed by Ru‐piano stool complexes and has been reported to be compatible with air, water, and thiol‐containing compounds such as glutathione. However, little is known about the true influence of biological components on the outcome of this reaction. The results presented herein reveal that the c… Show more
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