2024
DOI: 10.3390/cells13221894
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The Two Sides of Indoleamine 2,3-Dioxygenase 2 (IDO2)

Chiara Suvieri,
Maria Laura Belladonna,
Claudia Volpi

Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) and IDO2 originated from gene duplication before vertebrate divergence. While IDO1 has a well-defined role in immune regulation, the biological role of IDO2 remains unclear. Discovered in 2007, IDO2 is located near the IDO1 gene. Because of their high sequence similarity, IDO2 was initially thought to be a tryptophan (Trp)-degrading enzyme like IDO1. Differently from what expected, IDO2 displays extremely low catalytic activity toward Trp. Nevertheless, many studies, often … Show more

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