The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis

Bessis, Natacha; Guéry, Laurence; Mantovani, Alberto; Vecchi, Annunciata; Sims, John E.; Fradelizi, D; Boissier, Marie Christophe

doi:10.1002/1521-4141(200003)30:3<867::aid-immu867>3.0.co;2-m

Cited by 78 publications

(26 citation statements)

References 46 publications

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“…In contrast, plasma levels of IL-1Ra correlated positively with disease progression, possibly reflecting disease exacerbation (78). These data are in line with experimental in vitro and in vivo data showing that overexpression of IL-1RII in chondrocytes protected them from IL-1 stimulation (85), or that the transfer of cells overexpressing and releasing IL-1RII resulted in the inhibition of collagen-induced arthritis (52). These results, as well as the binding properties of IL-1RII (high affinity for IL-1, low affinity for IL-1ra), supported the development of IL-1RII as therapeutic molecule in rheumatoid arthritis (see below).…”

Section: The Decoy Receptor Il-1riisupporting

confidence: 86%

“…Gene-targeted mice overexpressing IL-1RII under the control of the human keratin gene promoter were resistant to PMA-induced chronic skin inflammation (51). Recombinant IL-1RII delivered via implanted human keratinocytes overexpressing soluble IL-1RII played a protective role in a mouse model of collagen-induced arthritis (52) and intravenous administration of soluble IL-1RII significantly reduced joint swelling and erosion in a model of arthritis in rabbit (53). Gene transfer of a soluble IL-1RII-Ig fusion protein reduced allograft rejection and prolonged graft survival in a rat model of heart transplantation, reduced infiltrating macrophages, and CD4+ T cells, and lowered levels of TNF-α and TGF-β (54).…”

Section: The Decoy Receptor Il-1riimentioning

confidence: 99%

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Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

et al. 2013

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Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signaling molecules and negative regulators. The latter include decoy receptors (IL-1RII; IL-18BP) and “receptors” with regulatory function (TIR8/SIGIRR; IL-1RAcPb; DIGIRR). Structural considerations suggest that also TIGIRR-1 and IL-1RAPL may have regulatory function. The presence of multiple pathways of negative regulation of members of the IL-1/IL-1R family emphasizes the need for a tight control of members of this fundamental system.

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Section: The Decoy Receptor Il-1riisupporting

confidence: 86%

Section: The Decoy Receptor Il-1riimentioning

confidence: 99%

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

et al. 2013

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“…Bessis et al used a collagen-induced arthritis murine model synonymous to human inflammatory arthritis to demonstrate the anti-inflammatory properties of sIL-1RtII. Human sIL-1RII-transfected keratinocytes engrated into arthritic mice decreased clinical and histological arthritis characteristics and decreased IL-6 and myeloperoixdase mRNA expression within the joints [37]. …”

Section: Novel Therapeutic Anti-il-1 Agentsmentioning

confidence: 99%

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

et al. 2006

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The tumor microenvironment consists of tumor, immune, stromal, and inflammatory cells which produce cytokines, growth factors, and adhesion molecules that promote tumor progression and metastasis. Of particular interest in this setting is interleukin-1 (IL-1), a pleiotropic cytokine with numerous roles in both physiological and pathological states. It is known to be up regulated in many tumor types and has been implicated as a factor in tumor progression via the expression of metastatic and angiogenic genes and growth factors. A number of studies have reported that high IL-1 concentrations within the tumor microenvironment are associated with a more virulent tumor phenotype. Solid tumors in which IL-1 has been shown to be up regulated include breast, colon, lung, head and neck cancers, and melanomas, and patients with IL-1 producing tumors have generally bad prognoses. The exact mechanisms by which IL-1 promotes tumor growth remain unclear, though the protein is believed to act via induction of pro-metastatic genes such as matrix metalloproteinases and through the stimulation of adjacent cells to produce angiogenic proteins and growth factors such as VEGF, IL-8, IL-6, TNFα, and TGFβ. The IL-1 receptor antagonist (IL1ra) is a naturally occurring inhibitor to IL-1 and acts by binding to the IL-1 receptor without activating it. The protein has been shown to decrease tumor growth, angiogenesis, and metastases in murine xenograft models. Our focus in this review is to summarize the known data on the role of IL-1 in tumor progression and metastasis and the use of IL-1 inhibition as a novel therapeutic approach in the treatment of solid organ malignancies.

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“…This is supported by data from a TNF-αoverexpressing transgenic mouse model, where treatment with antibodies to IL-1RI completely prevented the otherwise spontaneous arthritis (Ref. 111). A combinational therapy with both anti-TNF-α and anti-IL-1 has therefore been proposed (Ref.…”

Section: Discussionmentioning

confidence: 62%

Cartilage catabolism in arthritis: factors that influence homeostasis

Rowan

2001

Expert Rev. Mol. Med.

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Preventing the destruction of articular cartilage has long been a goal in the treatment of arthritic diseases, in which a combination of cytokines and growth factors affect the catabolic state of cells within the joint. Normal tissue turnover can be viewed as a balance between degradation and synthesis of the macromolecules that constitute the extracellular matrix. This process is tightly regulated such that highly degradative proteinases are controlled at several levels, including synthesis and secretion, activation and inhibition. Tissue destruction occurs when proteinase-mediated degradation exceeds synthesis, and this is markedly influenced by cytokines and growth factors that stimulate matrix synthesis as well as the production of proteinases and/or their endogenous inhibitors. This review outlines current knowledge of factors that influence cartilage biology, with particular emphasis on chondrocytes and synovial fibroblasts. Recent findings from the delivery of cytokines to affected tissues are also summarised, and the potential impact these observations might have on new therapies for arthritic diseases is discussed.

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The type II decoy receptor of IL-1 inhibits murine collagen-induced arthritis

Cited by 78 publications

References 46 publications

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

Decoys and Regulatory “Receptors” of the IL-1/Toll-Like Receptor Superfamily

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

Cartilage catabolism in arthritis: factors that influence homeostasis

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