The type of blood used to feed Aedes aegypti females affects their cuticular and internal free fatty acid (FFA) profiles

Kaczmarek, Agata; Wrońska, Anna Katarzyna; Boguś, Mieczysława I.; Kazek, Michalina; Gliniewicz, Aleksandra; Mikulak, Ewa; Matławska, Marta

doi:10.1371/journal.pone.0251100

Cited by 16 publications

(12 citation statements)

References 141 publications

(186 reference statements)

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“…Decanoic acid is a fatty acid that is a surface component of human skin [ 23 ] and is present in many plants. It is also a component of mosquito cuticular and internal lipids [ 24 ]. In our assay, decanoic acid was found to be attractive at the intermediate concentration and repellent at the high concentration for male Ae.…”

Section: Discussionmentioning

confidence: 99%

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

Carraretto¹,

Soresinetti²,

Rossi³

et al. 2022

Insects

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The Asian tiger mosquito, Aedes albopictus, has become one of the most important invasive vectors for disease pathogens such as the viruses that cause chikungunya and dengue. Given the medical importance of this disease vector, a number of control programmes involving the use of the sterile insect technique (SIT) have been proposed. The identification of chemical compounds that attract males can be very useful for trapping purposes, especially for monitoring the makeup of the male population during control programmes, such as those involving the use of the SIT. Twenty-eight chemical compounds from different chemical classes were evaluated using a dual-port olfactometer assay. The compounds included known animal, fungal and plant host volatiles, and components of a putative Aedes aegypti pheromone. Many of the compounds were repellent for male mosquitoes, especially at the highest concentration. One compound, decanoic acid, acted as an attractant for males at an intermediate concentration. Decanoic acid did not elicit a significant response from female mosquitoes.

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Section: Discussionmentioning

confidence: 99%

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

Carraretto¹,

Soresinetti²,

Rossi³

et al. 2022

Insects

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“…Changes in cuticle lipid profiles, occurring during normal development and after contact with the fungus, are the basis for selecting antifungal substances. The fatty acid contents of insects can vary according to their developmental stage, temperature, and dietary regime [38,42,57,59]. A previous study describing the metamorphosis-related changes in the FFA profiles of S. argyrostoma indicated the presence of C23:0 and C25:0 only in larvae, C28:0 in the pupal cuticle, and C12:1 and C18:3 in internal extracts from adults.…”

Section: Discussionmentioning

confidence: 99%

“…The masses of insects and the extracts are presented in Table 1. These methods expand upon those detailed within our previous work [37,38,57].…”

Section: Extraction Of Free Fatty Acids (Ffas)mentioning

confidence: 90%

The Impact of the Entomopathogenic Fungus Conidiobolus coronatus on the Free Fatty Acid Profile of the Flesh Fly Sarcophaga argyrostoma

Kaczmarek

Boguś

2021

Insects

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The chemical composition of the insect cuticle varies remarkably between species and their life stages. It can affect host resistance and substrate utilization by invading entomopathogen fungi, such as the soil fungus Conidiobolus coronatus. In this study, Sarcophaga argyrostoma flies were exposed to sporulating C. coronatus colonies for 24 h; the pupae were resistant, but the adults demonstrated 60% mortality. Although the pupae demonstrated no sign of infection nor any abnormal development, our findings indicate that after 24 h of contact with the fungus, the pupae demonstrated a 25.2-fold increase in total cuticular free fatty acids (FFAs) and a 1.9-fold decrease in total internal FFAs. Also, the cuticular FFA increased from 26 to 30, while the internal FFA class increased from 13 to 23. In exposed adults, the total mass of cuticular FFAs increased 1.7-fold, while the number of FFAs stayed the same (32 FFAs). Also, the internal FFA class increased from 26 to 35 and the total FFA mass increased 1.1-fold. These considerable differences between adults and pupae associated with C. coronatus exposure indicate developmental changes in the mechanisms governing lipid metabolism and spatial distribution in the organism, and suggest that cuticular lipids play a vital role in the defence against pathogenic fungi.

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“…Moreover, blood composition, and more specifically the fatty acid composition of lipids, varies with diet, age, gender, genetic background, and health status ( Hodson et al, 2008 ). As the blood source is an important parameter for the mosquito lipid profile, blood-induced metabolic changes vary among host donors ( Kaczmarek et al, 2021 ). A lipidome study from field-collected mosquitoes is likely to result in high variability, which could explain part of the variation in mosquito vector competence.…”

Section: Flaviviruses Subdue Phospholipids In Mosquitoesmentioning

confidence: 99%

Lipid Interactions Between Flaviviruses and Mosquito Vectors

et al. 2021

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Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.

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The type of blood used to feed Aedes aegypti females affects their cuticular and internal free fatty acid (FFA) profiles

Cited by 16 publications

References 141 publications

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

Behavioural Responses of Male Aedes albopictus to Different Volatile Chemical Compounds

The Impact of the Entomopathogenic Fungus Conidiobolus coronatus on the Free Fatty Acid Profile of the Flesh Fly Sarcophaga argyrostoma

Lipid Interactions Between Flaviviruses and Mosquito Vectors

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