2012
DOI: 10.3389/fmicb.2012.00066
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The Ubiquitin System and Kaposi’s Sarcoma-Associated Herpesvirus

Abstract: Ubiquitination is a post-translational modification in which one or more ubiquitin molecules are covalently linked to lysine residues of target proteins. The ubiquitin system plays a key role in the regulation of protein degradation, which contributes to cell signaling, vesicular trafficking, apoptosis, and immune regulation. Bacterial and viral pathogens exploit the cellular ubiquitin system by encoding their own proteins to serve their survival and replication in infected cells. Recent studies have revealed … Show more

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Cited by 24 publications
(27 citation statements)
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“…In fact, KSHV targets NF-κB signaling to influence gene expression and apoptosis. KSHV-encoded v-FLIP, K15, v-GPCR, K1 and K7 activate NF-κB signaling to achieve antiapoptosis in KSHV-infected cells, including PEL cells (4,6). Therefore, DAT-mediated destabilization of TRAF6 induces stabilization of IκBα and the subsequent inhibition of NF-κB signaling, which in turn may result in apoptosis of PEL cells.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…In fact, KSHV targets NF-κB signaling to influence gene expression and apoptosis. KSHV-encoded v-FLIP, K15, v-GPCR, K1 and K7 activate NF-κB signaling to achieve antiapoptosis in KSHV-infected cells, including PEL cells (4,6). Therefore, DAT-mediated destabilization of TRAF6 induces stabilization of IκBα and the subsequent inhibition of NF-κB signaling, which in turn may result in apoptosis of PEL cells.…”
Section: Discussionmentioning
confidence: 99%
“…Total RNA was purified and extracted from 1x10 6 cells using an Illustra RNAspin mini RNA Isolation kit (GE Healthcare, Buckinghamshire, uK). First-strand cDNA was synthesized from 20 ng of total RNA using a ReverTra Ace qPCR RT kit (Toyobo, Osaka, Japan).…”
Section: Reverse Transcription-polymerase Chain Reaction (Rt-pcr)mentioning
confidence: 99%
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“…Kaposi sarcoma‐associated herpesvirus modulates the ubiquitination pathway through LANA binding to Fbw7/Sel10 and suppressing NICD degradation (Figure C). In addition, increased expression of Hey‐1 is stabilized by LANA (Figure B).…”
Section: Introductionmentioning
confidence: 99%