The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: I. Study Methods

Romanenko, Anatoly; Bebeshko, Volodymir G.; Hatch, Maureen; Bazyka, Dimitry; Finch, Stuart C.; Dyagil, Iryna; Reiss, Robert F.; Chumak, Vadim; Bouville, André; Gudzenko, Nataliya; Zablotska, Lydia B.; Pilinskaya, M.; Lyubarets, Tatiana; Bakhanova, Elena; Babkina, Nataliya; Trotsiuk, N.; Ledoschuk, B.; Belayev, Yuri; Dybsky, S. S.; Ron, Elaine; Howe, Geoffrey R.

doi:10.1667/rr1402.1

Cited by 28 publications

(23 citation statements)

References 15 publications

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“…We ascertained potential cases of leukemia occurring within the cohort between 1986 and 2000 through computerized linkage (11) of cohort records and a Provisional Leukemia Registry (10). We established an expert international panel of five hematologists and hematopathologists to review all diagnoses (12).…”

Section: Methodsmentioning

confidence: 99%

The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks

Romanenko¹,

Finch²,

Hatch³

et al. 2008

Radiation Research

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Leukemia is one of the cancers most susceptible to induction by ionizing radiation, but the effects of lower doses delivered over time have not been adequately quantified. Following the Chornobyl (Chernobyl) accident in Ukraine in April 1986, several hundred thousand workers who were involved in cleaning up the site and its surroundings received fractionated exposure, primarily from external gamma radiation. To increase our understanding of the role of protracted low-dose radiation exposure in the etiology of leukemia, we conducted a nested case-control study of leukemia in a cohort of cleanup workers identified from the Chornobyl State Registry of Ukraine. The analysis is based on 71 cases of histologically confirmed leukemia diagnosed in 1986-2000 and 501 age-and residence-matched controls selected from the same cohort. Study subjects or their proxies were interviewed about their cleanup activities and other relevant factors. Individual bone marrow radiation doses were estimated by the RADRUE dose reconstruction method (mean dose=76.4 (SD=213.4) milligray (mGy)). We used conditional logistic regression to estimate leukemia risks. The excess relative risk of total leukemia was 3.44 per Gy (95% confidence interval 0.47-9.78, p<0.01). The dose-response was linear and did not significantly differ by calendar period of first work in the 30-km Chornobyl zone, duration or type of work. We found a similar dose-response relationship for chronic and non-chronic lymphocytic leukemia.

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Section: Methodsmentioning

confidence: 99%

The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks

Romanenko¹,

Finch²,

Hatch³

et al. 2008

Radiation Research

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“…Epidemiological study "The Ukrainian-American study of leukemia and related disorders among Chоrnobyl cleanup workers" was held on a cohort of 110,645 male cleanup workers from Ukraine. Leukemia, MDS, and multiple myeloma cases occurring during the period 1986 to 2000 were identified [14]. The cases of MDS were initially identified using the FAB system [6], later in 2007 they were reclassified according to the WHO system [7].…”

Section: Discussionmentioning

confidence: 99%

“…The cases of MDS were initially identified using the FAB system [6], later in 2007 they were reclassified according to the WHO system [7]. MDS was confirmed in 7 cases out of 139 ones initially referred to the expert panel, and one more case of MDS was reclassified using the WHO system as acute myelogenous leukemia, bringing the total for MDS to six [14].…”

Section: Discussionmentioning

confidence: 99%

Myelodysplastic Syndrome in Patients with Acute Radiation Syndrome Following the Chornobyl Nuclear Power Plant Accident

Liubarets¹,

Kovalenko²

2016

J Leuk

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The MDS cases (n=3) among acute radiation syndrome (ARS) survivors after the ChNPP accident were analyzed. MDS diagnoses were based on FAB (1982) and WHO classifications and included the refractory anemia (RA) (patient D. with ARS grade III), refractory anemia with ringed sideroblasts (RARS) (patient B. with ARS grade III), and unclassified MDS (MDS-U) (patient S. with ARS grade I). Clinical management of MDS in ARS patients was analyzed taking into consideration the morphological, immunological, and cytochemical peculiarities of haemopoietic cells. The ARS diagnoses were confirmed in a survey on a regular basis using standard cytogenetic method. Described MDS cases in ARS patients may be the secondary MDS variants taking into consideration possible radiation-induced injuries of hematopoietic cell genome due to the high dose of IR (1.7-5.5 Sv). The possible role of previous irradiation in a range of occupational dose limits before the ChNPP catastrophe for patients D. and B. with ARS grade III, both with possible role of such a confounding factor as petroleum exposure for patient S. (ARS grade I) for the development of MDS cannot be excluded.

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“…The persisting elevation of thyroid cancer risk in this population underscores the need to continue to follow these individuals to assess whether the excess risk persists or declines with time. A case-control study of leukemia among clean-up workers who, unlike residents, received primarily wholebody protracted external radiation found a significant increase in risk of total leukemia with evidence of an increase in leukemias other than chronic lymphocytic leukemia and in chronic lymphocytic leukemia (15).…”

Section: Intentional and Accidental Releases Of Radiationmentioning

confidence: 99%

Evolving Strategies in Epidemiologic Research on Radiation and Cancer

González¹,

Brenner²,

Hartge³

et al. 2011

Radiation Research

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The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: I. Study Methods

Cited by 28 publications

References 15 publications

The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks

The Ukrainian-American Study of Leukemia and Related Disorders among Chornobyl Cleanup Workers from Ukraine: III. Radiation Risks

Myelodysplastic Syndrome in Patients with Acute Radiation Syndrome Following the Chornobyl Nuclear Power Plant Accident

Evolving Strategies in Epidemiologic Research on Radiation and Cancer

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