The ultrastructure of pinealomas

Nishimoto, Akira

doi:10.1007/bf00684834

Cited by 37 publications

(5 citation statements)

References 25 publications

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“…To our knowledge, no specific work has yet addressed the relation between pineal tumors and ER stress. Only ultrastructural studies showed signs of ER enlargement in pinealoblastomas, pinealocytomas and papillary tumors (Jouvet et al, 2003;Kline et al, 1979;Tabuchi et al, 1973). However, special reference should be done about the role of melatonin in ER stress mechanisms.…”

Section: Er Stress In Primary Brain Cancersmentioning

confidence: 95%

Signaling the Unfolded Protein Response in primary brain cancers

et al. 2016

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The Unfolded Protein Response (UPR) is an adaptive cellular program used by eukaryotic cells to cope with protein misfolding stress in the Endoplasmic Reticulum (ER). During tumor development, cancer cells are facing intrinsic (oncogene activation) and extrinsic (limiting nutrient or oxygen supply; exposure to chemotherapies) challenges, with which they must cope to survive. Primary brain tumors are relatively rare but deadly and present a significant challenge in the determination of risk factors in the population. These tumors are inherently difficult to cure because of their protected location in the brain. As such surgery, radiation and chemotherapy options carry potentially lasting patient morbidity and incomplete tumor cure. Some of these tumors, such as glioblastoma, were reported to present features of ER stress and to depend on UPR activation to sustain growth, but to date there is no clear general representation of the ER stress status in primary brain tumors. In this review, we describe the key molecular mechanisms controlling the UPR and their implication in cancers. Then we extensively review the literature reporting the status of ER stress in various primary brain tumors and discuss the potential impact of such observation on patient stratification and on the possibility of developing appropriate targeted therapies using the UPR as therapeutic target.

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Section: Er Stress In Primary Brain Cancersmentioning

confidence: 95%

Signaling the Unfolded Protein Response in primary brain cancers

et al. 2016

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“…Mehanizam kojim nastaju tumori u području pinealne žlijezde još je uvijek nepoznat. Pretpostavlja se da stres endoplazmatskog retikuluma (ER), koji je udružen s njegovim povećanjem, ima određenu ulogu u karcinogenezi tumora parenhima pinealne žlijezde [15][16][17][18] . Nadalje, s obzirom na to da tumori pinealne žlijezde zadržavaju sposobnost lučenja melatonina, pretpostavlja se da bi upravo taj hormon mogao imati bitnu ulogu u nastanku tih tumora 19 .…”

Section: Raspravaunclassified

Pinealni parenhimni tumor intermedijarnog stupnja diferencijacije – prikaz slučaja

et al. 2018

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Sažetak. Cilj:Prikazati slučaj pacijentice s pinealnim parenhimnim tumorom intermedijarnog stupnja diferencijacije gradus II, s naglaskom na patohistološku dijagnozu ovog kliničkog entiteta. Prikaz slučaja: Tridesetosmogodišnja pacijentica primljena je na Kliniku za neurokirurgiju Kliničkog bolničkog centra Rijeka radi operativnog liječenja ciste pinealne regije. Osnovni i jedini simptomi bile su glavobolje unatrag četiri godine. Magnetska rezonancija mozga ukazivala je na cističnu tvorbu pinealne regije. Učinjena je osteoklastična subokcipitalna medijana kraniotomija s ekstirpacijom ciste pinealne regije te je bioptički uzorak poslan na patohistološku analizu. Histološki je utvrđeno oskudno tkivo mozga infiltrirano umjereno celularnim tumorskim tkivom građenim od difuzno raspoređenih, malih uniformnih stanica oskudne citoplazme s tendencijom stvaranja perivaskularnih acelularnih područja i diskretnim pineocitomatoznim rozetama. Jezgre tumorskih stanica bile su ovalne, monomorfnog izgleda s mjestimičnom blagom polimorfijom. Mitotska aktivnost bila je niska i iznosila je manje od 0,5 %. U bioptičkom uzorku bilo je nekoliko manjih žarišta kalcifikacije, ali bez prisutnosti nekroze. Imunohistokemijska analiza pokazala je izrazitu difuznu obojenost na neuron specifičnu enolazu (engl. neuron-specific enolase, NSE) i znakove neuroendokrine diferencijacije, o čemu svjedoči snažna difuzna obojenost na sinaptofizin. Na temelju histološke slike i imunohistokemijskog profila zaključeno je da pregledani materijal predstavlja pinealni parenhimni tumor intermedijarnog stupnja diferencijacije -WHO gradus II. Pacijentica se nakon operacije osjećala dobro i otpuštena je na kućno liječenje. Zaključci: Jedino ispravno postavljena patohistološka dijagnoza može dovesti do odgovarajućeg izbora terapije i ispravnog kliničkog pristupa pacijentu s pinealnim parenhimnim tumorom intermedijarnog stupnja diferencijacije. Daljnja molekularna istraživanja bila bi korisna patologu u postavljanju standarda i izradi smjernica koje bi pomogle u postavljanju točne dijagnoze. Abstract. Aim:To report a case of a patient with the pineal parenchymal tumor of intermediate differentiation grade II, with emphasis on histopathological diagnosis of this clinical entity. Case report: A 30-year-old patient was admitted at the Clinic for Neurosurgery at the Clinical Hospital Centre Rijeka in order to surgically remove a cyst in the pineal region. The only and main symptoms were headaches in the past four years. Magnetic resonance was performed to visualize the pineal cyst. Osteoclastic suboccipital median craniotomy with extirpation of the cyst had been done and the biopsy specimen was sent to the Pathology Department of the Clinical Hospital Centre Rijeka. Histologically, the tissue of the brain was infiltrated by a moderately cellular tumor tissue consisting of diffusely distributed small uniform cells with scarce cytoplasms and with the tendency to form perivascular acellular areas with discrete pineocytomatous rosettes. Nuclei of the tumor cells were oval ...

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“…Giesma stain, x 3.5. lar tumor in the anterior hypothalamic region which invaded the floor of the third ventricle, the pituitary stalk and large portions of the pituitary gland with almost complete replacement of the neurohypophysis and both infiltration and compression of the adenohypophysis. The histology of this tumor was that of a germinoma or so-called ectopic anisomorphic pinealoma of the two-cell type; its light and electron microscopial identity to the seminomas and dysgerminomas of the gonads is now well docu mented [G hatak et al, 1969;Warczok and Arnold, 1972;O swald and H ed in g er, 1972;T abuchi et al, 1973;J ellinger, 1973], In patients suffering from ectopic pinealomas or lesions of hypothal amic area adipsia was previously reported by several authors [Christie and Ross, 1968;G oldberg et al, 1967;K astin et al, 1965;M addy and W internitz, 1972;L ascelles and Lew is, 1972; T runigr and Kunzler, 1962; Sohn and P ittman, 1972], It was observed that a state of transient stimulation of the thirst center accompanied by polydipsia and polyuria can precede a state of absence of thirst [Truniger and K unzler, 1962]. We assume that a similar mechanism took place in the patient during the time of anamnestic polydipsia.…”

Section: Discussionmentioning

confidence: 99%

Excessive Hypernatremia and Hyperosmolality Associated with Germinoma in the Hypothalamic and Pituitary Region

Zazgórnik¹,

Jellinger²,

Waldhäusl³

et al. 1974

Eur Neurol

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A 17-year-old boy with excessive hypernatremia, hyperchloremia and hyperosmolality caused by an intra- and suprasellar germinoma was studied. Destruction of hypothalamic thirst and osmoregulation centers were responsible for these disturbances. The extra- and intracellular space were reduced, the exchangeable sodium was 2.5 times normal. Urinary gravity was 1,022 following dehydration, indicating that the patient could produce endogenous vasopressin. The syndrome was accompanied by normal urinary excretion of aldosterone in the presence of a high plasma renin concentration (PRC) of 4.5 X 10^–4 GU/ml. There was a partial impairment of pituitary function for the release of HGH and possibly also for ACTH.

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The ultrastructure of pinealomas

Cited by 37 publications

References 25 publications

Signaling the Unfolded Protein Response in primary brain cancers

Signaling the Unfolded Protein Response in primary brain cancers

Pinealni parenhimni tumor intermedijarnog stupnja diferencijacije – prikaz slučaja

Excessive Hypernatremia and Hyperosmolality Associated with Germinoma in the Hypothalamic and Pituitary Region

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