The Unambiguous Detection of Kaurenic Derivatives in Aqueous Infusions of<i>Montanoa tomentosa</i>by GC-MS and 2D-NMR Spectroscopy: An Answer to Contradictory Reports

Enríquez, Raúl G.; Miranda, Elena; Ortíz, B.; Leon, Ismael; Magos, Gil A.; Peña, Araceli; Reynolds, WF; Gnecco, Dino

doi:10.1055/s-2006-957976

Cited by 9 publications

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“…Successive recrystallizations of the chloroform-soluble portion, using n -hexane−diethyl ether and freezing, afforded monoginoic acid ( 8 , 23.6 mg). Physical and spectroscopic data matched those in the literature …”

Section: Methodssupporting

confidence: 77%

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Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants

et al. 2007

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The antiproliferative bioassay-guided fractionation of five Peruvian plants, Doliocarpus dentatus, Picramnia sellowii, Strychnos mitscherlichii, Iryanthera juruensis, and Croton alnifolius, led to the isolation and identification of their different major cytotoxic constituents, betulinic acid (1), nataloe-emodin (2), bisnordihydrotoxyferine (4), 2',4'-dihydroxy-6'-methoxy-3,4-methylenedioxydihydrochalcone (5), and 2',4'-dihydroxy-4,6'-dimethoxydihydrochalcone (6) and 12-O-tetradecanoylphorbol-13-acetate (7), respectively. Eight human tumor cell lines and two nontumorigenic cell lines were used in this investigation. Their in vitro activity against Mycobacterium tuberculosis is also reported.

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Section: Methodssupporting

confidence: 77%

“…The isolation of TPA from C. alnifolius represents a potentially alternative natural source for this important pharmacological tool. The structures of these compounds were identified by comparing their spectroscopic data with those reported previously …”

Section: Resultsmentioning

confidence: 99%

Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants

et al. 2007

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“…3 Some authors attribute some of the pharmacological properties of M. tomentosa principally to the diterpenic acids, kaurenoic acid (KA; kaur-16-en-18-oic acid) and grandiflorenic acid [GA; kaura-9 (11), 16-dien-18-oic acid]. 4 However, other compounds may also play relevant roles.…”

Section: Introductionmentioning

confidence: 99%

“…tomentosa has been extensively studied for its medicinal properties, mainly those attributed to diterpenic acids such as kaurenoic, grandiflorenic and monoginoic acids. 4 The functional properties of these acids have opened a very interesting research area. Kaurenoic acid is common to all plants, because it is the precursor of gibberellins biosynthesis.…”

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confidence: 99%

Volatile organic compounds of leaves and flowers ofMontanoa tomentosa

et al. 2006

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The leaves and flowers of Lavandula dhofarensis were collected from the Dhofar region of Oman and hydro-distilled to give low boiling volatiles, which did not condense at 10 o C. The dichloromethane extract of the hydrosol was analyzed by GC/FID and GC/MS. Sixty four compounds were identified in the volatiles of the leaves, accounting for 78.7% of the total. The major components were caryophyllene oxide (8.0%), germacrene (7.9%), spathulenol (7.8%), and -caryophyllene (6.6%). Eighty six compounds were also identified in the volatiles of the leaves plus flowers, comprising 94.5% of the total. The major compounds were camphor (12.9%), viridiflorol (10.5%), -terpinyl acetate (7.5%), valerenal (7.2%), -gurjunene (5.6%), and spathulenol (5.5%). Compounds such as linalool, linalyl acetate, 1,8-cineole, and -ocimene, which are usually found as the major components of lavender oils, were either absent or detected at low levels (<0.1%) in the hydrosol of L. dhofarensis. This investigation showed that the fragrance essence of L. dhofarensis is different from the other Lavandula species. L. dhofarensisis is regionally endemic to wetter areas of Oman.

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“…in aqueous extracts of plants used in traditional medicine, may be confirmed from the presence of characteristic cross peaks in COSY and/or 1 H-13 C shift correlation spectra. 7 An alternative approach is to use the HR-DOSY sequence which can generate separate subspectra for different components of a mixture, provided that they have different have diffusion coefficients. 8 Finally, coupled techniques such as HPLC-NMR show great promise for investigations of complex mixtures of natural products, 9 but this requires that the components be separable by HPLC.…”

Section: Resultsmentioning

confidence: 99%

Identification and complete spectral assignment for two 4?-methylsterols in an inseparable mixture using 2D NMR

et al. 2001

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The Unambiguous Detection of Kaurenic Derivatives in Aqueous Infusions ofMontanoa tomentosaby GC-MS and 2D-NMR Spectroscopy: An Answer to Contradictory Reports

Cited by 9 publications

References 0 publications

Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants

Isolation of Cytotoxic Metabolites from Targeted Peruvian Amazonian Medicinal Plants

Volatile organic compounds of leaves and flowers ofMontanoa tomentosa

Identification and complete spectral assignment for two 4?-methylsterols in an inseparable mixture using 2D NMR

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