Objective: The main purpose of this study was to verify if non-cardiac chest pain (NCCP) subjects recruited in an Emergency Department were more anxious, depressive or burdened by somatoform symptoms as compared with cardiac chest pain (CCP) subjects, and with subjects without chest pain (WOCP).
Methods:We included patients with chest pain not attributable to a gastro-oesophageal reflux disorder. NCCP subjects were negative at ECG examination and at troponin test at baseline and after three months. A number of instruments were administered, measuring anxiety and depression (HADS), somatisation (somatisation scale of , and the health-related QoL (SF-12), along with other scales measuring the social and experiential profile.
Results:We recruited 435 subjects (of which NCCP were 44.8%) in the Emergency Department, while other 147 subjects were recruited in a primary care clinic. The logistic regression showed that the levels of HADS anxiety in the three groups were dissimilar, even when adjusted for confounding variables: taking NCCP as reference category, adjusted ORs were 0.64 for CCP (IC95% 0.42 -0.96) and 0.23 for WOCP (IC95% 0.13 -0.40). When considering the somatisation construct, CCP and NCCP subjects reported similar somatic symptom complaints, higher than WOCP subjects. Moreover, even if NCCP subjects showed higher TAS-20 scores than WOCP subjects, these scores were below the range of a possible alexithymia. As for the physical health-related QoL (SF-12, subscale PCS-12), regression analyses showed that the PCS-12 mean score of NCCP was higher than that of CCP (ß -2.31; IC95% -4.14 to -0.48) and lower than that of WOCP (ß 2.24; IC95% 0.12 -4.37).Conclusion: NCCP subjects are characterised from an elevated anxiety, together with a better physical well-being, when compared with subjects who have a cardiac failure. The somatisation construct seems less useful to distinguish NCCP from CCP subjects. Consequently, anxiety should be the major target of our mental-health intervention when treating subjects with chest pain.Citation: Balestrieri M, Isola M, Gangi F, Sbrojavacca R, PResT-ED (2016) When considering the somatisation approach, we may refer to the systematic review carried out by Crombez et al. [5], which analysed the concept of somatisation in empirical studies of pain. This review was able to identify 116 studies, most of which used the SCL-90 scale. Of these, only four studies explicitly investigated whether the somatisation symptoms were unaccounted for by organic findings, and none was focused on cardiac or chest pain. The results were inconclusive because of the poor quality of the studies identified.In synthesis, so far the literature is poorly characterised by comprehensive studies that compared NCCP and cardiac chest pain (CCP) subjects for the presence of anxiety/depression on one side and somatisation on the other side. The main aims of this study were: to characterize patients with NCCP in terms of anxious, depressive and somatoform symptoms, to compare these symptoms with those of ...