Nighttime light observations from remote sensing provide us with a timely and spatially explicit measure of human activities, and therefore enable a host of applications such as tracking urbanization and socioeconomic dynamics, evaluating armed conflicts and disasters, investigating fisheries, assessing greenhouse gas emissions and energy use, and analyzing light pollution and health effects. The new and improved sensors, algorithms, and products for nighttime lights, in association with other Earth observations and ancillary data (e.g., geo-located big data), together offer great potential for a deep understanding of human activities and related environmental consequences in a changing world. This paper reviews the advances of nighttime light sensors and products and examines the contributions of nighttime light remote sensing to perceiving the changing world from two aspects (i.e., human activities and environmental changes). Based on the historical review of the advances in nighttime light remote sensing, we summarize the challenges in current nighttime light remote sensing research and propose four strategic directions, including: Improving nighttime light data; developing a long time series of consistent nighttime light data; integrating nighttime light observations with other data and knowledge; and promoting multidisciplinary and interdisciplinary analyses of nighttime light observations.