The uncommon syndrome of pancreatic encephalopathy

Mittal, Saumya H; Govil, Tuhina

doi:10.4103/2349-0977.191047

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…The development of this encephalopathy is rooted in a multifactorial process involving the cytokine storm, the penetration of pancreatic enzymes into the central nervous system due to blood-brain barrier damage, and hemodynamic dysfunction linked to AP. 8 In our patient, typical flu-like symptoms and respiratory involvement preceded pancreatitis. Notably, there were no other risk factors for AP, such as a history of gallstones or alcoholism.…”

Section: Case Descriptionsupporting

confidence: 47%

Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation

Bairwa,

Narayanan,

Jithesh

et al. 2024

Indian Journal of Critical Care Case Report

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Instances of the H1N1 influenza virus contributing to acute pancreatitis (AP) are indeed rare. Similarly, pancreatic encephalopathy (PE) represents an unusual complication of AP that is often underdiagnosed and unreported. Here, we present a unique case involving influenza-induced pancreatitis and subsequent PE in a middle-aged female who initially presented with acute shortness of breath, complaints of abdominal pain, and altered sensorium. A nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) for influenza A confirmed the infection with H1N1. Ultrasonography of the abdomen and contrast-enhanced computed tomography revealed features indicative of AP. Due to the altered sensorium, a noncontrast computed tomography (NCCT) of the brain was conducted, yielding normal results. Cerebrospinal fluid (CSF) analysis also returned normal results. With a regimen of conservative management for pancreatitis and treatment with oseltamivir, the patient experienced improvement in both shortness of breath and sensorium. This case underscores the unusual manifestation of influenza-related complications and emphasizes the significance of a multidisciplinary approach to diagnosis and management.

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Section: Case Descriptionsupporting

confidence: 47%

Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation

Bairwa,

Narayanan,

Jithesh

et al. 2024

Indian Journal of Critical Care Case Report

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“…Pancreatic encephalopathy was first described in 1923 by Lowell (49). It can lead to a syndrome of neuropsychiatric disorders, which makes it a significant problem for clinicians (50).…”

Section: Tab 1 Atlanta Classification Of Individual Disease Entitiesmentioning

confidence: 99%

“…ROS (reactive oxygen species) also play an important role in the pathogenesis of AP (54). They are assumed to be responsible for the development of local and systemic inflammatory reactions (49). They are also mediators of cell damage, as they initiate the peroxidation of membrane lipids, thus causing their dysfunction (52).…”

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confidence: 99%

Changes in noradrenaline and dopamine levels under oxygen debt conditions in the brain of rats during experimental acute pancreatitis

Markiewicz-Gospodarek¹,

Łuszczewska-Sierakowska²,

Kuszta³

et al. 2022

Medycyna Weterynaryjna

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This study’s aim was to assess the level of catecholamines, i.e., noradrenaline and dopamine, under oxygen debt conditions in the brain of experimental animals in which acute pancreatitis was experimentally induced. Catecholamines play the role of neurotransmitters and neuromediators. They are responsible for the regulation of motor and emotional processes, take part in the regulation of hormonal activities, sleep, wakefulness, concentration, attention, and learning processes. The experiment also determined the oxygen tension as an indicator of respiratory failure and the activity of amylase and lipase in the development of the inflammatory process. The animals on which the experiment was conducted were Wistar rats (140 animals) divided into 3 research groups: control (C) animals (n = 30), healthy (H) animals (n = 30), and operated (O) animals (n = 80). The determination of amylase, lipase, oxygen pressure, NA, and DO levels were performed at hours 2, 6, 12, 24, and 48 of the experiment. The animals in group C had an injection needle inserted to investigate only the effects of mechanical damage to the organs. On the other hand, the animals in group O had a 5% solution of sodium taurocholate introduced into the common bile-pancreatic duct. The research conducted shows that the most significant changes in NA and DO levels were observed on the first day of the experiment. The concentrations of the above catecholamines were statistically significantly correlated with the level of amylase in the blood. The peak of dopamine was observed between the 6th and 12th hours of the experiment, while the lowest concentration of noradrenaline was observed at the 6th hour of the experiment.

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Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis

Бебуришвили¹,

Burchuladze²,

Mikhin³

et al. 2022

Khir. Z. im. N.I. Pirogova

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The uncommon syndrome of pancreatic encephalopathy

Cited by 3 publications

References 2 publications

Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation

Influenza-induced Pancreatitis and Pancreatic Encephalopathy: A Rare Clinical Presentation

Changes in noradrenaline and dopamine levels under oxygen debt conditions in the brain of rats during experimental acute pancreatitis

Prediction and diagnosis of pancreatogenic encephalopathy in patients with destructive pancreatitis

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