Multi-stage hydraulic fracturing (MsHF) is the main technology to improve hydrocarbon recovery from shale plays. Associated with their rich organic contents and laminated depositional environments, shales exhibit transverse isotropic (TI) characteristics. In several cases, the lamination planes are horizontal in shale formations with a symmetric axis that are vertical to the bedding plane; hence, shale formations are known as transverse isotropic vertical (TIV) rocks. Ignoring the TIV nature of shale formations leads to erroneous estimates of in situ stresses and consequently to inefficient designs of fractural geometry, which negatively affects the ultimate recovery. The goal of this study is to investigate the effects of TIV medium characteristics on fractural geometry, spacing, and stress shadow development in the Jurassic Tuwaiq Mountain formation (TMF) in the Jafurah basin, which is a potential unconventional world-class play. This formation is the main source for prolific Jurassic oil reservoirs in Saudi Arabia. On the basis of a petrophysical evaluation in the Jafurah basin, TMF exhibited exceptional unconventional gas characteristics, such as high total organic content (TOC) and low clay content, and it was in the proper maturity window for oil and gas generation. The unconventional Jafurah field covers a large area that is comparable to the size of the Eagle Ford shale play in South Texas, and it is planned for development through multi-stage hydraulic fracturing technology. In this study, analytical modeling was performed to estimate the fractural geometry and in situ stresses in the anisotropic medium. The results show that the Young’s modulus anisotropy had a noticeable impact on fractural width, whereas the impact of Poisson’s ratio was minimal. Moreover, we investigated the impact of stress anisotropy and other rock properties on the stress shadow, and found that a large stress anisotropy could result in fractures being positioned close to one another or theoretically without minimal fractural spacing concerns. Additionally, we estimated the fractural aspect ratio in different propagation regimes and observed that the highest aspect ratio had occurred in the fractural toughness-dominated regime. This study also compares the elastic properties and confirms that TMF exhibited greater anisotropic properties than those of Eagle Ford. These findings have practical implications for field operations, particularly with regard to the fractural geometry and proppant placement.