2016
DOI: 10.1093/bfgp/elw001
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The understanding of circular RNAs as special triggers in carcinogenesis

Abstract: Circular RNAs (circRNAs) are a large type of noncoding RNAs characterized by their circular shape resulting from covalently closed continuous loops. They are known to regulate gene expression in mammals. These tissue-specific transcripts are largely generated from exonic or intronic sequences of their host genes. Although several models of circRNA biogenesis have been proposed, the understanding of their origin is far from complete. Unlike other noncoding RNAs, circRNAs are widely expressed, highly conserved a… Show more

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Cited by 51 publications
(50 citation statements)
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“…A convergence of evidence suggests that circRNAs may play a key regulatory role in cancer (Li et al, ; Zhao and Shen, ; Xin et al, ). For example, Foxo3 circRNA slowed cell cycle progression by forming ternary complexes with p21 and CDK2 (Du et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…A convergence of evidence suggests that circRNAs may play a key regulatory role in cancer (Li et al, ; Zhao and Shen, ; Xin et al, ). For example, Foxo3 circRNA slowed cell cycle progression by forming ternary complexes with p21 and CDK2 (Du et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…23 However, recent evidences showed that circRNAs can be regulatory RNAs, just like miRNA and long non-coding RNAs, participating in several biological processes. Therefore, F I G U R E 7 cMras affected cell proliferation in vivo.…”
Section: Discussionmentioning
confidence: 99%
“…They are more stable than linear RNA because of their closed loop structure, which prevents degradation by RNA exonuclease, providing richness to circRNAs [8-10]. Studies have reported that circRNAs play an important role in many diseases, including preeclampsia, Alzheimer's disease, diabetes, and tumors [11-14]. CircRNA can act as miRNA sponges [15-18], thereby adsorbing miRNA and removing the inhibitory effect of miRNA on its target genes, resulting in the upregulation of target genes.…”
Section: Introductionmentioning
confidence: 99%