The undescended testis: considerations and impact on fertility

Leissner,; Filipas,; Wolf, Jason; Fisch,

doi:10.1046/j.1464-410x.1999.00093.x

Cited by 55 publications

(59 citation statements)

References 36 publications

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“…About 10% of testicular cancers occur in an undescended testis (2). Men with an undescended testis have impaired spermatogenesis (azoospermia or oligozoospermia in 50-70%), and infertility (2,4).…”

Section: Introductionmentioning

confidence: 99%

Screening for Y microdeletions in men with testicular cancer and undescended testis

Bor¹,

Hindkjær²,

Kølvraa³

et al. 2006

J Assist Reprod Genet

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Purpose : To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. Methods : It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions Results : A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. Conclusions : Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.

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Section: Introductionmentioning

confidence: 99%

Screening for Y microdeletions in men with testicular cancer and undescended testis

Bor¹,

Hindkjær²,

Kølvraa³

et al. 2006

J Assist Reprod Genet

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“…Cryptorchidism can be unilateral or bilateral and, on the basis of its location, can be classified as abdominal, canalicular, ectopic, or retractile (Leissner et al 1999). The abdominal testis is often located at the internal inguinal ring, the canalicular testis is located within the canal or at the top of the scrotum, and the ectopic testis is out of its normal pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Cryptorchidism is associated with a higher risk of developing testicular tumors in adulthood, the risk being five-to tenfold greater than in normal men (Woodhouse 1991;United Kingdom Testicular Cancer Study Group 1994). To produce viable and mature spermatozoa, testicular temperature must be 1.5°C-2.0°C below body temperature; thus undescended testes also cause infertility (Leissner et al 1999).…”

Section: Introductionmentioning

confidence: 99%

A novel mutation of the insulin-like 3 gene in patients with cryptorchidism

et al. 2003

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homozygote wild type. We also found three polymorphic changes, previously reported in exon 1. The Asn-intoLys change is likely deleterious because it leads to a nonconservative amino acid substitution, changing a highly conserved residue. This mutation, located in the A-chain of the INSL3 protein, is the first mutation reported in this region. This finding provides new evidence that INSL3 is involved in testicular descent in humans; however, mutations of this gene are not a frequent cause of cryptorchidism.

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“…Le risque de canc~risation d'un testicule non descendu est 35 a 50 fois sup~rieur ~ celui d'une glande en place [7,8,16,18,28]. Le type histologique le plus fr~quement retrouv~ est le s~minome (52% des cas), suivi du sarcome (18%), du teratome (15%), du carcinome embryonnaire (10%) et enfin le choriocarcinome (5%) [14,21,28].…”

Section: Discussionunclassified