The unfulfilled gene and nervous system development in Drosophila

Bates, Karen E.; Molnár, J.; Robinow, Steven

doi:10.1016/j.bbagrm.2014.06.013

Cited by 3 publications

(2 citation statements)

References 65 publications

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“…The unfulfilled ( HR51 ) gene was named on the basis of the mutant phenotype in which eclosed adults fail to unfold their wings and exhibit reduced fertility [167,168]. In mushroom bodies, it functions in specifying neuron identities and regulating axon pathfinding [169].…”

Section: Unf/fax-1/pnr (Nr2e3)mentioning

confidence: 99%

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Bodofsky¹,

Koitz²,

Wightman³

2017

Nuclear Receptor Research

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The nuclear receptor gene family includes 18 members that are broadly conserved among multiple disparate animal phyla, indicating that they trace their evolutionary origins to the time at which animal life arose. Typical nuclear receptors contain two major domains: a DNA-binding domain and a C-terminal domain that may bind a lipophilic hormone. Many of these nuclear receptors play varied roles in animal development, including coordination of life cycle events and cellular differentiation. The well-studied genetic model systems of Drosophila, C. elegans, and mouse permit an evaluation of the extent to which nuclear receptor function in development is conserved or exapted (repurposed) over animal evolution. While there are some specific examples of conserved functions and pathways, there are many clear examples of exaptation. Overall, the evolutionary theme of exaptation appears to be favored over strict functional conservation. Despite strong conservation of DNA-binding domain sequences and activity, the nuclear receptors prove to be highly-flexible regulators of animal development.

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Section: Unf/fax-1/pnr (Nr2e3)mentioning

confidence: 99%

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Bodofsky¹,

Koitz²,

Wightman³

2017

Nuclear Receptor Research

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“…69, 70 Anatomical profiling has detected low level NR2E3 expression in the enteric tract and in seminal vesicles 71 suggesting possible PNR functions in other tissues. Moreover, cell line expression studies indicate co-expression of PNR and PPARγ in cells of tumor origin.…”

Section: Discussionmentioning

confidence: 99%

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations

et al. 2017

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Photoreceptor-specific nuclear receptor (PNR/NR2E3) and Tailless homolog (TLX/NR2E1) are human orthologs of the NR2E group, a subgroup of phylogenetically related members of the nuclear receptor (NR) superfamily of transcription factors. We assessed the ability of these NRs to form heterodimers with other members of the human NRs representing all major subgroups. The TLX ligand-binding domain (LBD) did not appear to form homodimers or interact directly with any other NR tested. The PNR LBD was able to form homodimers, but also exhibited robust interactions with the LBDs of peroxisome proliferator-activated receptor-γ (PPARγ)/NR1C3 and thyroid hormone receptor b (TRb) TRβ/NR1A2. The binding of PNR to PPARγ was specific for this paralog, as no interaction was observed with the LBDs of PPARα/NR1C1 or PPARδ/NR1C2. In support of these findings, PPARγ and PNR were found to be co-expressed in human retinal tissue extracts and could be co-immunoprecipitated as a native complex. Selected sequence variants in the PNR LBD associated with human retinopathies, or a mutation in the dimerization region of PPARγ LBD associated with familial partial lipodystrophy type 3, were found to disrupt PNR/PPARγ complex formation. Wild-type PNR, but not a PNR309G mutant, was able to repress PPARγ-mediated transcription in reporter assays. In summary, our results reveal novel heterodimer interactions in the NR superfamily, suggesting previously unknown functional interactions of PNR with PPARγ and TRβ that have potential importance in retinal development and disease.

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DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogaster

Phelps¹

2019

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The unfulfilled gene and nervous system development in Drosophila

Cited by 3 publications

References 65 publications

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Conserved and Exapted Functions of Nuclear Receptors in Animal Development

Heterodimers of photoreceptor-specific nuclear receptor (PNR/NR2E3) and peroxisome proliferator-activated receptor-γ (PPARγ) are disrupted by retinal disease-associated mutations

DHR51 as a coordinator of heme biosynthesis and steroid hormone production to time metamorphosis in Drosophila melanogaster

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