Using a nationally representative dataset (Early Childhood Longitudinal Study-Birth Cohort) and bioecological-cumulative disadvantage framework, the present study examined school readiness among American Indian and Alaska Native (AIAN) children. It investigated the relations between salient child and family risk experiences (i.e., poverty, preterm/low birth weight, low maternal education, single motherhood, inadequate prenatal care, teen motherhood, and severe maternal depression), and kindergarten academic (i.e., reading and math) and behavioral outcomes (i.e., social competence, approaches to learning, and externalizing behaviors). Descriptive statistics (representative of children born in 2001) revealed 58.5% of AIAN children experienced poverty at least once prior to kindergarten entry and 45% experienced two or more risks. Hierarchical linear regression examining cumulative risk counts