2007
DOI: 10.1016/j.cub.2007.02.058
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The Universal Dynamics of Cell Spreading

Abstract: Cell adhesion and motility depend strongly on the interactions between cells and extracellular matrix (ECM) substrates. When plated onto artificial adhesive surfaces, cells first flatten and deform extensively as they spread. At the molecular level, the interaction of membrane-based integrins with the ECM has been shown to initiate a complex cascade of signaling events [1], which subsequently triggers cellular morphological changes and results in the generation of contractile forces [2]. Here, we focus on the … Show more

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Cited by 257 publications
(361 citation statements)
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“…As such, its "effective" mechanical thickness would be significantly higher than the thickness measured using optical methods (6). This explanation is in line with observations of cortical rheology at long timescales, where a considerably elevated effective thickness is required to recover the rate of cell spreading using a simple Newtonian liquid model (8).…”
Section: Introductionsupporting
confidence: 70%
See 1 more Smart Citation
“…As such, its "effective" mechanical thickness would be significantly higher than the thickness measured using optical methods (6). This explanation is in line with observations of cortical rheology at long timescales, where a considerably elevated effective thickness is required to recover the rate of cell spreading using a simple Newtonian liquid model (8).…”
Section: Introductionsupporting
confidence: 70%
“…http://dx.doi.org/10.1101/343038 doi: bioRxiv preprint first posted online Jun. 8, 2018; List of Tables 1 Table of Biophysical Journal 00(00) [1][2][3][4][5][6][7][8][9][10] . CC-BY-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.…”
mentioning
confidence: 99%
“…The early state of aggregate spreading is driven by the capillary force per unit length of the contact line (28,29), F c ¼ γ cos θþ γ SO − γ CS ¼ W CS þ γðcos θ − 1Þ, where θ is the dynamic contact angle shown in Fig. 1A.…”
Section: Universal Early Dynamics Of Spreadingmentioning
confidence: 99%
“…Since the pioneering work by Steinberg in the 1960s (17), several studies have shown that the mechanical behavior of tissues and cellular aggregates can be characterized through their liquid-like behavior (18,19). The analogy between tissues and liquids has been very fruitful in describing the spreading of tissues, using the physics of capillarity and wetting (13,20). The statics of wetting has been previously described in ref.…”
mentioning
confidence: 99%