Abstract. We prove that relative functors out of a cofibration category are essentially the same as relative functors which are only defined on the subcategory of cofibrations. As an application we give a new construction of the functor that assigns to a groupoid its groupoid C * -algebra and thereby its topological K-theory spectrum.Let (C, wC, cC) be a cofibration category, i.e. a structure dual to a category of fibrant objects in the sense of Brown [Bro73]. Here, wC and cC are the subcategories of weak equivalences and cofibrations, i.e. they have the same objects as C but morphisms are the weak equivalences or the cofibrations respectively. Similarly, wcC will denote the subcategory of acyclic cofibrations. In addition to Brown's axioms, we will assume that C has good cylinders which is a mild technical condition explained in Definition 9. In this paper we will prove the following theorem.
Theorem 1. If a cofibration category C has good cylinders, then the map induced by the inclusionis an equivalence of ∞-categories. In particular, by passing to homotopy categories, we obtain an equivalence of ordinary categories cC[wcBy NC[w . By passing to opposite categories, the dual statement of Theorem 1 for fibration categories also holds.The proof of Theorem 1 will be given at the end of the paper, but let us first establish a consequence and the application to C * -algebras associated to groupoids. Let C be a small cofibration category with good cylinders and M a model category which is Quillen equivalent to a combinatorial model category and has functorial fibrant and cofibrant replacements, e.g. any of the model categories of spectra. (1) F sends weak equivalences in C to weak equivalences in M.(2) F extends F in the sense that there exists a zig-zag of natural weak equivalences between F and F | cC .Moreover F is unique in the following sense: for any other functor F ′ : C → M that satisfies (1) and (2) there exists a zig-zag of natural weak equivalences between F and F ′ .Proof. We denote the ∞-category NM[w −1 ] associated to the model category M by M ∞ . We claim that for any ordinary category A the canonical mapis an equivalence of ∞-categories, where ℓ is the class of levelwise weak equivalences. If M is a simplicial, combinatorial model category this is a special case of [Lur09, Proposition 4.2.4.4] using that for a simplicial model category M, the ∞-category M ∞ is equivalent to the homotopy coherent nerve of the simplicial subcategory of M on the fibrant and cofibrant objects, see