Purpose: This study examines how entrepreneurial ecosystem factors (entrepreneurial finance, entrepreneurial education, physical and commercial infrastructure, culture, and R&D transfer activities) shape social entrepreneurial activities (SEA) of men and women. Design/methodology/approach: Panel data from 35 countries are examined through General Methods of Moments (GMM) with Arellano Bond tests for the period of ten years (2005-2014). Findings: Our results indicate that women are more likely to get involved in creation of social ventures. Further, the selected six entrepreneurial factors modify SEA in a significantly different manner for both genders. Originality/value: Based on this analysis, this study is the first to provide deeper insights for improving the assessment of social entrepreneurial activities in efficiency and innovation driven economies within the entrepreneurial ecosystem.