The unusual behavior of the Gibbs’ reagent versus Nitrofural

Abstract

The study covers a new qualitative analytic test (method) for detecting the semicarbazone chemotherapeutic Nitrofural. The combination of Gibbs' reagent and ammonia was successfully implemented for analyzing the drug. The main structural features of the obtained color products were determined by UV-VIS spectroscopy.

Electrochemical detection of Nitrofural in the presence of sodium amminepentacyanoferrate (II)

“…Synthesis of sodium amminepentacyanoferrate (II) 5 : A 250 ml pyrex screw-capped reagent bottle was charged with 10 g of sodium nitroprusside, 6.0 g of sodium acetate and 75 ml of concentrated NH 4 OH. After keeping the mixture below 5°C overnight (in a refrigerator), the bright yellow crystals formed were filtered off by suction.…”

“…As a rule, the qualitative pharmacopoeial analysis is intended to confirm the identity of pharmaceutical raw materials at the so-assigned "acceptable" level of assurance (at the "second identification" stage). One of the positives of this analytical approach is its allowing a visual indication (analytical confirmation) of the chemical composition of the drug analyzed in toto or, partially of its peculiar structural motif (3)(4)(5). Therefore, in particular nowadays, the pharmacopoeial qualitative analysis is being widely used as a powerful analytical "instrument" for the identification of many drug raw materials, including the one examined here (2,4).…”