The Up-and-Down Method with Small Samples

Abstract

JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. American Statistical Association is collaborating with JSTOR to digitize, preserve and extend access to Journal of the American Statistical Association.

Synthesis and Antiallergic Activity of Dimethyl-2-(phenylcarbamoyl)ethylsulfoniump-Toluenesulfonate Derivatives

“…To ascertain the biological effects of the hydroxy substituent attached to the propoxy moiety, the toxicity of compounds 4j − m was tested. Compound 4j bearing no hydroxy group had high toxicity, a 2- or 3-hydroxypropoxy moiety ( 4l , 4m ) had reduced toxicity, and a 2,3- dihydroxypropoxy moiety ( 4k ) had the lowest toxicity according to the value of LD 50 (Table ). These results suggested that the hydroxy moiety of the propoxy substituent may have an effect of reducing toxicity.…”

“… a The value of LD 50 was determined in male ddY mice ( n = 5) by the up−down method described in ref . …”