The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy &amp; cervical cytopathology collaborative group (C5 group) approach

Kyrgiou, Maria; Tsoumpou, Ioanna; Vrekoussis, Thomas; Martin-Hirsch, P; Arbyn, Marc; Prendiville, Walter; Mitrou, S.; Koliopoulos, George; Dalkalitsis, N; Stamatopoulos, P; Paraskevaidis, Evangelos

doi:10.1016/j.ctrv.2006.07.008

Cited by 97 publications

(65 citation statements)

References 32 publications

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“…After completing the selection process, data from a total of eight studies involving 526 patients ( Figure 1) systematically was analyzed. All of them studied the association between TS expression and response to pemetrexedcontaining chemotherapy [6,[22][23][24][25][26][27][28][29][30][31].…”

Section: Selection Of Studiesmentioning

confidence: 99%

The Pemetrexed-Containing Treatments in the Non-small Cell Lung Cancer, Is -/Low Thymidylate Synthase Expression Better than +/High Thymidylate Synthase Expression? A Meta-analysis

Wang

Pan

et al. 2014

Chest

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Background: The predictive value of thymidylate synthase (TS) for clinical sensitivity to pemetrexed-containing chemotherapy in patients with non-small cell lung cancer (NSCLC) remains controversial. This meta-analysis is performed to provide an assessment of whether expression variations of TS are associated with objective response in patients with NSCLC treated with pemetrexed-containing chemotherapy. Methods: An electronic search was conducted using the databases MEDLINE, EMBASE and CNKI, from inception to June 10 th , 2013. A systemic review of the studies on the association between TS expression in NSCLC and objective response of pemetrexed-containing regimen was performed. Pooled odds ratios (OR) for the response rate were calculated using the software Revman 5.0.Results: There were a total of 526 patients in the eight studies that met our criteria for evaluation. +/high expression of TS was found in 269 patients (51.1%), and -/low expression for this gene was found in 257 (48.9%) patients. The objective response rate for pemetrexed-containing chemotherapy was significantly higher in patients with -/low expression TS expression (OR = 0.45; 95% CI, 0.29-0.70; p = 0.0004). Although patients with -/low expression of TS have a longer median overall survival time and progression free survival time than those with +/high expression of TS, the difference was not statistically significant.Conclusions: −/low expression of TS was associated with higher objective response in NSCLC patients treated with pemetrexed-containing chemotherapy. TS may be a suitable marker of sensitivity to pemetrexed-based chemotherapy in patients with NSCLC.

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Section: Selection Of Studiesmentioning

confidence: 99%

The Pemetrexed-Containing Treatments in the Non-small Cell Lung Cancer, Is -/Low Thymidylate Synthase Expression Better than +/High Thymidylate Synthase Expression? A Meta-analysis

Wang

Pan

et al. 2014

Chest

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“…Nowadays treatment of choice for HSILs is a Large Loop Excision of the Transformation Zone (LLETZ). Advantages of this method are the simplicity of the procedure and the production of a specimen for histological diagnosis, thereby allowing assessment of the excision margins [7]. Using therapy in an outpatient setting to treat HSIL reduces the risk of cervical cancer by 95% in the first 8 years after therapy [8].…”

Section: Introductionmentioning

confidence: 99%

Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ)

Eijsink

Bock

Kuiper

et al. 2009

Gynecologic Oncology

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Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ) Eijsink, J. J. H.; de Bock, G. H.; Kuiper, J. L.; Reesink-Peters, N.; van Hemel, B. M.; Hollema, H.; Nijman, H. W.; Mourits, M. J. E.; van der Zee, A. G. J. Objective. To assess the compliance of HSIL patients to the national Dutch routine follow-up protocol in the first 2 years after LLETZ and to determine if based on the status of excision margins, follow-up intervals could be modified.Methods. A prospective cohort study was performed in patients, referred because of an abnormal Pap smear between 1996 and 2004 and treated for HSIL with LLETZ. The Dutch national routine follow-up protocol orders a Pap smear after 6, 12 and 24 months, respectively. Follow-up results were completed by using PALGA, the nationwide network and registry of histo-and cytopathology in the Netherlands. To assess compliance to the follow-up protocol, adequate follow-up was defined as three cervical smears taken after 6 (+/− 3), 12 (+/− 3) and 24 (+/− 3) months, respectively.Results. Compliance to the first 2 years follow-up protocol declined from 86.2% to 64.8% to 51.2% for first, second and third follow-up cervical smears, respectively. Patients with involved excision margins had a three times higher overall risk of developing a subsequent HSIL after LLETZ as compared to patients with free excision margins (HR: 3.2, 95% CI = 1.3-7.9, p = 0.01). Risk for diagnosing HSIL during the first 12 months of follow-up for patients with free excision margins was only 1%.Conclusions. Compliance to the Dutch national routine follow-up protocol in HSIL patients after LLETZ is only moderate. For HSIL patients with free excision margins after LLETZ the first cytological follow-up interval can safely be increased to 12 months.

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“…The precancerous lesions CIN and adenocarcinoma in situ (AIS) can be effectively treated with the various available surgical interventions and laser ablation (ectocervical CIN) [5][6][7]. Loop excision is the most commonly used method, which, in contrast to e.g.…”

Section: Introductionmentioning

confidence: 99%

The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias

Friebe

Klapdor

Hillemanns

et al. 2017

Geburtshilfe Frauenheilkd

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Introduction In this retrospective study partial genotyping of human papilloma viruses (HPV) using the Abbott RealTime HighRisk HPV Test (RealTime) was compared with simple HPV detection (Qiagen Hybrid Capture 2 Test; hc2) for recurrence prediction at the first follow-up examination after conization of cervical intraepithelial neoplasia (CIN). Methods 144 women who had undergone conization for CIN between January 2007 and December 2013 were included. HPV status was determined preoperatively and at first follow-up using hc2 in 103 women and RealTime in 41 women. Recurrent or persistent CIN was assumed when CIN2+ was confirmed histologically or on comparable cytology findings. Results Of the 144 women with complete data 12 (8.3%) had a recurrence after conization. HPV persistence at follow-up correlated significantly with recurrence (hc2: p = 0.003; RealTime: p = 0.003) and both sensitivity and specificity were high (hc2 = 100 and 78.4% respectively; RealTime = 75.0 and 83.9%). Whereas isolated HPV testing had a relatively low positive predictive value for recurrence (hc2 16%; RealTime 54.5%), this rose to 80% with HPV 16 detection at follow-up. Conclusion At follow-up after conization of CIN the combination of high risk HPV detection and partial genotyping of HPV 16 constitutes excellent diagnostic criteria for recurrence/persistence of CIN.

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The up-to-date evidence on colposcopy practice and treatment of cervical intraepithelial neoplasia: The cochrane colposcopy & cervical cytopathology collaborative group (C5 group) approach

Cited by 97 publications

References 32 publications

The Pemetrexed-Containing Treatments in the Non-small Cell Lung Cancer, Is -/Low Thymidylate Synthase Expression Better than +/High Thymidylate Synthase Expression? A Meta-analysis

The Pemetrexed-Containing Treatments in the Non-small Cell Lung Cancer, Is -/Low Thymidylate Synthase Expression Better than +/High Thymidylate Synthase Expression? A Meta-analysis

Routine follow-up intervals in patients with high-grade squamous intraepithelial lesions (HSIL) and free excision margins can safely be increased in the first two years after Large Loop Excision of the Transformation Zone (LLETZ)

The Value of Partial HPV Genotyping After Conization of Cervical Dysplasias

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