The updated cancer paradigm of PAH: recognizing complexity

Szulcek, Robert; Grune, Jana; Kuebler, Wolfgang M.

doi:10.1152/ajplung.00159.2020

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…58 In addition, differential expression of circRNAs has been found in various diseases. 59 Therefore, circRNAs may contribute to the pathogenesis of many diseases. In terms of molecular mechanisms, circRNAs are reported to serve as miRNA sponges, RBP sponges, key mediators at the transcriptional and post-transcriptional levels, parental gene regulators, and can translate amino acids into peptides and proteins (Figure 2B).…”

Section: B Iolog Ic Al Char Ac Teriz Ation Of Circrna Smentioning

confidence: 99%

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

Qian

Sun

Zhao

et al. 2022

Anim Models and Exp Med

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Circular RNAs (circRNAs) are endogenous RNAs with a covalently closed single‐stranded transcript. They are a novel class of genomic regulators that are linked to many important development and disease processes and are being pursued as clinical and therapeutic targets. Using the most powerful RNA sequencing and bioinformatics techniques, a large number of circRNAs have been identified and further functional studies have been performed. It is known that circRNAs act as potential biomarkers, sponges for microRNAs (miRNAs) and RNA‐binding proteins (RBPs), and regulators of mRNA transcription. They also participate in the translation of peptides or proteins. Many types of circRNAs are dysregulated in plasma or lung tissues, and they may be involved in regulating the proliferation and apoptosis of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs), leading to pulmonary vascular remodeling in pulmonary hypertension (PH). One possible mechanism is that circRNAs can regulate the function of PAECs and PASMCs by acting as miRNA sponge. However, other potential mechanisms of action of circRNAs are still being actively explored in PH. This paper presents a systematic review of the biogenesis, biological characterization, relevant underlying functions, and future perspectives for studies of circRNAs in the pathogenesis of PH.

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Section: B Iolog Ic Al Char Ac Teriz Ation Of Circrna Smentioning

confidence: 99%

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

Qian

Sun

Zhao

et al. 2022

Anim Models and Exp Med

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Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension

Jimenez

Hawn

Akin

et al. 2022

Biochemical Pharmacology

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Health benefits of liquid smoke from various biomass sources: a systematic review

Surboyo,

Baroutian,

Puspitasari

et al. 2024

BIOI

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Liquid smoke, a product of the pyrolysis process, includes components such as phenol, furfural, and ketones, and has acidic characteristics. Liquid smoke from various biomass sources has been used as a natural preservative worldwide and reported to be safe in humans. As a bio-economic product, liquid smoke has human health benefits. This review analyzes and describes the health benefits of liquid smoke from various biomass sources, according to in silico, in vitro, and in vivo studies. A systematic review following PRISMA guidelines was conducted to identify published reports of liquid smoke from various biomass sources. The anti-inflammatory, anti-bacterial, anti-diabetic, wound healing, and anti-periodontitis activity of liquid smoke was analyzed. Prior research has investigated liquid smoke produced through pyrolysis of various biomass types, such as rice husks (Oryza sativa), coconut shells (Cocos nucifera L.), palm kernels ( Elaeis guineensis Jacq.), cocoa pods ( Theobroma cacao L .), tian op, and hickory ( Carya tomentosa (Lam.) Nutt .), as well as commercial liquid smoke. Toxicity testing, and in vitro and in vivo studies, are required for the assessment of health benefits. Therapeutic benefits of liquid smoke including anti-oxidant, anti-inflammatory, anti-nociceptive, anti-bacterial, anti-fungal, and anti-viral activity have been described. Further health benefits include anti-diabetic, anti-periodontitis, wound healing, and ulcer healing activity. These findings increase the use value of liquid smoke as a natural product with human health benefits.

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The updated cancer paradigm of PAH: recognizing complexity

Cited by 3 publications

References 15 publications

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

Circular RNAs in pulmonary hypertension: Emerging biological concepts and potential mechanism

Translational potential of targeting Anoctamin-1-Encoded Calcium-Activated chloride channels in hypertension

Health benefits of liquid smoke from various biomass sources: a systematic review

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