The Updated Review on Plant Peptides and Their Applications in Human Health

Mani, Saiprahalad; Bhatt, Smruti B.; Vasudevan, Vinduja; Prabhu, Dhamodharan; Rajamanikandan, Sundararaj; Velusamy, P.; Ramasamy, Palaniappan; Pachaiappan, Raman

doi:10.1007/s10989-022-10437-7

Cited by 16 publications

(4 citation statements)

References 204 publications

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“…Over two-thirds of these are sulfur-containing peptides. Various studies have reported on the antitumoral, antimicrobial, neuroregulating and antiviral (anti-HIV) properties of phytopeptides and thionins [68,[72][73][74][75]. This difference in the compositions of the small peptides in the hellebore samples compared to our previously reported results [11] confirms that the profile of the secondary metabolites is determined by various endogenous or ecological factors, plant components, extraction methods and solvent polarities [40][41][42][76][77][78].…”

Section: Screening and Classification Of The Differential Metabolitessupporting

confidence: 72%

Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

Segneanu,

Vlase,

Vlase

et al. 2023

Plants

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The current nanomedicinal approach combines medicinal plants and nanotechnology to create new scaffolds with enhanced bioavailability, biodistribution and controlled release. In an innovative approach to herb encapsulation in nanosized chitosan matrices, wild-grown Romanian Helleborus purpurascens was used to prepare two new chitosan nanocarriers. The first carrier preparation involved the nanoencapsulation of hellebore in chitosan. The second carrier emerged from two distinct stages: hellebore-AgNPs phyto-carrier system succeeded by nanoencapsulation in chitosan. The morphostructural characteristics and thermal behavior of these newly prepared nanocarriers were examined using FT-IR, XRD, DLS, SEM, EDS and thermogravimetric analyses. In addition, the encapsulation yield, encapsulation efficiency and encapsulation contents were investigated. The antioxidant activity was estimated using four in vitro, noncompetitive methods: total phenolic assay; 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay; phosphomolybdate (i.e., total antioxidant capacity); and iron(III)-phenanthroline antioxidant assay. Moreover, this study reports the first low-molecular-weight metabolite profile of wild-grown Romanian Helleborus purpurascens Waldst. & Kit. A total of one hundred and five secondary metabolites were identified in the mass spectra (MS)-positive mode from fourteen secondary metabolite categories (alkaloids, butenolides, bufadienolides, phytoecdysteroids, amino acids and peptides, terpenoids, fatty acids, flavonoids, phenolic acids, sterols, glycosides, carbohydrates, nucleosides and miscellaneous). The collective results suggest the potential application is a promising new antioxidant vehicle candidate in tumor therapeutic strategy.

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Section: Screening and Classification Of The Differential Metabolitessupporting

confidence: 72%

Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

Segneanu,

Vlase,

Vlase

et al. 2023

Plants

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“…3b and c). 30,31,39 All given characteristic peaks of naproxen were also observed in the FTIR graphs of naproxen/HPβCD (1/1) IC and naproxen/ HPβCD (1/2) IC nanofibrous films and this proved the existence of naproxen molecules in these samples (Fig. 3b and c).…”

Section: Rsc Medicinal Chemistry Research Articlementioning

confidence: 57%

“…30 As was reported previously, this shortcoming of naproxen can be dissolved by forming inclusion complexes with different types of CD molecules. [30][31][32][33][34][35][36][37] Even, in a related study by Séon-Lutz et al, hyaluronic acid/PVA nanofibers were incorporated with the inclusion complexes of hydroxypropyl-beta-cyclodextrin (HPβCD) and naproxen for the purpose of wound dressing applications. 38 In another study reported by the Uyar group, poly(ε-caprolactone) (PCL) nanofibers were functionalized with naproxen/βCD inclusion complexes that provided an enhanced release profile for the drug molecule compared to the CD-free system.…”

Section: Introductionmentioning

confidence: 99%

Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films

Celebioglu,

Dash,

Aboelkheir

et al. 2024

RSC Med. Chem.

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“…Recent research is focused on the study of the potential activity of the peptides in the therapeutic field in the scavenging activity of the free radical, which promises to develop a peptide-based drug. 10 The superior methods are used in identifying the presence of secondary metabolites functional peptides against optimized digestion conditions, such as substrate concentration, pH, hydrolysis period, temperature, and enzyme/substrate ratio, that simulate the standard functionality of the human body conditions and will be the evolving research in the future. [11][12][13] The "accidents of chemistry" lead to the constant production of oxygen-derived species such as free radicals.…”

Section: Introductionmentioning

confidence: 99%

HPLC purification of antioxidant and antibacterial peptides from a lichen “Parmotrema perlatum (Huds.) M. Choisy”: Identification by LC‐MS/MS peptide mass fingerprinting

Radhakrishnan,

Kanakaraja,

Krishnan

et al. 2024

Biotech and App Biochem

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Parmotrema perlatum, a lichen belonging to the family Parmeliaceae, is well known for its culinary benefits and aroma used as a condiment in Indian homes is also known as the “black stone flower” or “kalpasi” in India. This research intends to analyze the antioxidant power of the crude extracts using four pH‐based buffers solubilized proteins/peptides and RP‐HPLC fractions of P. perlatum obtained by purification. The proteins that were extracted from the four different buffers were examined using LC‐MS/MS‐based peptide mass fingerprinting. When compared to the other buffers, the 0.1 M of Tris‐HCl buffer pH 8.0 solubilized proteins/peptides had the strongest antioxidant capacity. The sequential purification of the peptide was carried out by using a 3‐kDa cut‐off membrane filter and semipreparative RP‐HPLC. Additionally, the purified fractions of the peptide's antioxidant activity were assessed, and effects were compared with those of the crude and 3 kDa cut‐‐off membrane filtrates. The peptide fractions were sequenced by LC‐MS/MS, which reveals that fraction 2 from RP‐HPLC with the sequence LSWFMVVAP has shown the highest antioxidant potential in comparison with other fractions which can serve as the potential natural antioxidant drug. Further, fraction 2 also showed antibacterial activity against the selected microorganisms.

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The Updated Review on Plant Peptides and Their Applications in Human Health

Cited by 16 publications

References 204 publications

Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

Formulation of a fast-disintegrating drug delivery system from cyclodextrin/naproxen inclusion complex nanofibrous films

HPLC purification of antioxidant and antibacterial peptides from a lichen “Parmotrema perlatum (Huds.) M. Choisy”: Identification by LC‐MS/MS peptide mass fingerprinting

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