2020
DOI: 10.1172/jci.insight.132364
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The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP

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Cited by 14 publications
(33 citation statements)
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References 60 publications
(147 reference statements)
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“…We examined the histopathology of the sciatic nerve of these four groups of mice at the age of 6 weeks. In accordance with previous studies (Musner et al, 2016; Sidoli et al, 2016; Stone et al, 2020), we found that PERK inactivation in SCs alone did not change SC numbers or myelin integrity in the PNS (Figures 7, 8, 9, 10). P0 immunostaining showed that the immunoreactivity of P0 was comparable in the sciatic nerve of Double cKO mice, Sel1L cKO, PERK cKO mice, and control mice (Figure 7a–d).…”
Section: Resultssupporting
confidence: 93%
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“…We examined the histopathology of the sciatic nerve of these four groups of mice at the age of 6 weeks. In accordance with previous studies (Musner et al, 2016; Sidoli et al, 2016; Stone et al, 2020), we found that PERK inactivation in SCs alone did not change SC numbers or myelin integrity in the PNS (Figures 7, 8, 9, 10). P0 immunostaining showed that the immunoreactivity of P0 was comparable in the sciatic nerve of Double cKO mice, Sel1L cKO, PERK cKO mice, and control mice (Figure 7a–d).…”
Section: Resultssupporting
confidence: 93%
“…Additionally, a recent study showed that deletion of Derlin-2 in SCs does not affect developmental myelination in the PNS (Volpi et al, 2019 (Huang, Hsiao, Chu, Ye, & Chen, 2013;Lilley & Ploegh, 2005); however, Sel1L is essential for the ERAD activity of the Sel1L-Hrd1 complex. Therefore, these data likely reflect that ERAD impairment in loss and demyelination in the CNS at P45, there is no evidence of SC dysfunction or death in the PNS of these mice at P45 (Stone et al, 2020). In fact, in accordance to the study, we showed here that double deletion of PERK and Sel1L did not attenuate the viability or function of SCs in the PNS at the age of 6 weeks, and that Sel1L cKO mice did not display evidence of SC dysfunction or death at the age of 10 weeks.…”
Section: Discussionmentioning
confidence: 83%
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