The upregulation of Na+,K+-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate

Antia, I.J.; Smith, Claire; Wood, A. J. J.; Aronson, Jeffrey K

doi:10.1016/0165-0327(94)00102-f

Cited by 19 publications

(8 citation statements)

References 29 publications

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“…The decrease in activity among bipolars is seen only when ill individuals are compared with euthymic patients, and occurs independently of the type of treatment [Li alone (Naylor et al, 1973Nurnberger et al, 1982), antidepressant alone (Nurnberger et al, 1982;Rybakowski et al, 1981), various combinations of drugs (Nurnberger et al, 1982), or ECT alone (Choi et al, 1977)], as well as in unmedicated patients (Naylor et al, 1973Rybakowski et al, 1981). The apparent lack of medication effect is consistent with the observation that lymphocytes obtained from bipolar individuals do not upregulate Na,K-ATPase when exposed to lithium as do cells obtained from normal controls or unaffected family members of bipolar probands (Antia et al, 1992(Antia et al, , 1995Wood et al, 1991). The finding that Na,K-ATPase activity in bipolar patients is not different from that in control is consistent with the interpretation that this is a state-dependent, rather than a trait-related, phenomenon.…”

Section: Discussionmentioning

confidence: 70%

Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness

1997

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Sodium, potassium‐activated adenosine triphosphatase (Na,K‐ATPase) pump activity has been variously reported to be increased, decreased, or unchanged in bipolar patients. To explore this association we conducted a meta‐analysis of the available literature. All papers containing data on erythrocyte Na,K‐ATPase activity were reviewed independently by both authors. A meta‐analysis of these data was accomplished by standard procedure. We found a significant mood‐state‐related decrease in Na,K‐ATPase activity in both manic and bipolar depressed patients when compared to euthymic bipolar patients, but not when ill patients were compared to normal controls. The overall change can be characterized as small to moderate in magnitude. Depression and Anxiety 5:53–65, 1997. © 1997 Wiley‐Liss, Inc

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Section: Discussionmentioning

confidence: 70%

Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness

1997

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“…Sex-related differences in lymphocyte Na,K-ATPase may solely be related to their activability (Vereninov et al, 1993;Buttgereit et al, 2000;Marakhova et al, 2005). However, if the idea that lymphocyte Na,K-ATPase may represent its brain counterpart is correct (Antia et al, 1992(Antia et al, , 1995 these results might have broader implications.…”

Section: Discussionmentioning

confidence: 74%

“…of its activity in connection with brain physio-pathological states (Antia et al, 1992(Antia et al, , 1995.…”

Section: Introductionmentioning

confidence: 99%

SEX DIFFERENCES IN HUMAN LYMPHOCYTE Na,K-ATPase AS STUDIED BY LABELED OUABAIN BINDING

Scarrone

Balestrino

Frassoni

et al. 2007

International Journal of Neuroscience

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Lymphocytes Na,K-ATPase is a plasma membrane enzyme that is up-regulated under lymphocytes activation. It is also studied as a model of brain cells Na,K-ATPase. Data about sex-related specificities of the enzyme are not available. The binding of tritium-labelled ouabain to lymphocyte plasma membrane Na,K-ATPase was studied in healthy volunteers of both sexes. The binding interactions were expressed in terms of K(D) and B(Max). The first parameter is related to the affinity of ouabain for the enzyme whereas the second one is related to its density on the cell membrane. Distinct sex-related differences were found. Whereas in males there is a significant direct correlation between the parameters K(D) and B(Max), in females this is not present. However, in females there is a significantly lower K(D) in the 25-37 age range. The latter result probably reflects the expression of subunit variants giving a greater affinity for ouabain. This circumstance may be relevant both to lymphocytes' ability to be activated and to brain function, if one admits that lymphocyte Na,K-ATPase faithfully represents the brain-borne one.

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“…A decreased Na, K ATPase activity has been described as a state marker in acutely ill bipolar patients as it is not seen in healthy relatives (Antia, Smith, Wood, & Aronson, 1995). Besides lithium, also CBZ is capable to stimulate the Na, K ATPase causing a reduction of intracellular calcium (Wood, Elphick, & Grahame-Smith, 1989).…”

Section: Effects Of Acs On Intracellular Messaging Systemsmentioning

confidence: 98%

Anticonvulsants in bipolar disorder

Grunze

2010

Journal of Mental Health

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Anticonvulsant drugs are widely used in psychiatric indications. This includes alcohol and benzodiazepine withdrawal symptoms, panic and anxiety disorders, dementia, schizophrenia, and to some extent personality disorders. Besides pain syndromes, their main domain outside epilepsy, however, is bipolar disorder. Carbamazepine, valproate, and lamotrigine are meanwhile recognized mood stabilizers, but several other antiepileptic drugs have also been tried out with diverging or inconclusive results. Understanding the mechanisms of action and identifying similarities between anticonvulsants effective in bipolar disorder may also enhance our understanding of the underlying pathophysiology of the disorder.

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The upregulation of Na+,K+-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate

Cited by 19 publications

References 29 publications

Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness

Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness

SEX DIFFERENCES IN HUMAN LYMPHOCYTE Na,K-ATPase AS STUDIED BY LABELED OUABAIN BINDING

Anticonvulsants in bipolar disorder

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