The ups and downs of anorexia nervosa

Lucas,; Crowson,; O'Fallon,; Melton, Joe R.

doi:10.1002/(sici)1098-108x(199912)26:4<397::aid-eat5>3.3.co;2-s

Cited by 33 publications

(46 citation statements)

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“…Furthermore, the affected age of anorexia nervosa patients overlaps with the period of peak bone formation. The risk of lifetime fracture in anorexia nervosa patients is about 2·9 times the norm (Lucas et al 1999).…”

Section: Introductionmentioning

confidence: 74%

“…Especially in anorexia nervosa, estrogen deficiency is one of the contributing factors, because the degree of bone loss is directly correlated with the duration of amenorrhea (Biller et al 1989). Hypercortisolism, present in about 22% of patients, can also accelerate bone loss (Lucas et al 1999). Another worrisome problem might be an increase in the PTH concentration during food restriction.…”

Section: Discussionmentioning

confidence: 99%

“…Neither daily calcium supplements for 23 months nor estrogen replacement for 1 year increased the BMD in osteopenic patients with anorexia nervosa (Rigotti et al 1991, Klibanski et al 1995. A 6-day trial of low dose rhIGF-I in women with anorexia nervosa increased the carboxyl-terminal propeptide of the type 1 procollagen (PICP) by up to 21·6%, without any evidence of enhanced bone resorption (Lucas et al 1999). However, the clinical application of IGF-I has several limitations, such as short plasma half-life and some side effects, including hypoglycemia and parotid swelling (Guler et al 1989, Kovacs et al 1999.…”

Section: Discussionmentioning

confidence: 99%

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The effects of recombinant human parathyroid hormone, rhPTH(1-84), on bone mass in undernourished rats

Rhee

Namgung

et al. 2002

Journal of Endocrinology

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Energy intake restriction reduces bone formation both in protein-energy malnourished children and in undernourished rats, and such conditions might cause partial or irreversible bone loss. Because the use of anti-resorptive agents in this situation is seemingly limited, we examined the effect of the anabolic agent, recombinant human parathyroid hormone (rhPTH(1-84)), on bones in undernourished conditions. First, the osteopenic changes of rat bones with 40% restricted diet for 4 weeks were confirmed. Subsequently, another set of the rats were randomized into four groups and studied for 8 weeks: the freely fed group (control group); the restricted diet, then freely fed group (restriction-ad libitum group); the restricted diet-vehicle-treated group (restriction-vehicle group); and the restricted diet-PTH-treated group (restriction-PTH group). In the restriction-vehicle group, total femoral bone mineral density (BMD) was lower and femoral length was shorter than the control group by 15·4% and 8·1% respectively (P<0·05). In the restriction-ad libitum group, these parameters recovered fully to those of the control group. In the case of intermittent PTH treatment in the persistent undernourished state, the BMD of total femur caught up with those of the control or the restriction-ad libitum group. However, the femoral length remained shorter than those of the other groups. Serum osteocalcin was significantly reduced in continuously undernourished rats, whereas it was elevated in the restriction-PTH group. In conclusion, BMD of total femur was low in undernourished rats. However, it increased after re-feeding ad libitum or intermittent PTH treatment. We suggest that rhPTH(1-84) may be a possible therapeutic agent for ongoing bone loss, especially in patients in a chronically undernourished condition.

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Section: Introductionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effects of recombinant human parathyroid hormone, rhPTH(1-84), on bone mass in undernourished rats

Rhee

Namgung

et al. 2002

Journal of Endocrinology

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“…These results were replicated by Lucas et al (1999) using updated incidence rates, and adding the new cases diagnosed with AN from 1985 through 1989. The upward trend in incidence rates was still observed in adolescents 15-to 19-year-old, as well as a noted rise among 10-to 14-year-old females between 1950 and 1989.…”

Section: Indicators Of An Increase Of Anmentioning

confidence: 99%

“…A comparative analysis of the previous 50 years' research has revealed continuance of the linear increase for 15 to 24-year-old females, possibly because of the vulnerability of this age group to social and psychological pressures (Lucas et al, 1999). In 1985 the estimated prevalence of AN among 15 to 19-year-old girls in Rochester was 0.48% (Lucas et al, 1991).…”

Section: Indicators Of An Increase Of Anmentioning

confidence: 99%

The Epidemic of Anorexia Nervosa: Myth or Reality?

Torres¹,

Guerra²,

Vieira³

et al. 2012

Relevant Topics in Eating Disorders

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Time trends in healthcare‐detected incidence of anorexia nervosa and bulimia nervosa in the Norwegian National Patient Register (2010–2016)

Reas

Rø

2018

Intl J Eating Disorders

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Objective: Few studies have investigated temporal trends in the incidence of eating disorders (EDs). This study investigated time trends in the age-and sex-specific incidence of healthcaredetected anorexia nervosa (AN) and bulimia nervosa (BN) from 2010 to 2016. Methods: Data were retrieved from the Norwegian National Patient Register as defined by the International Classification of Diseases (ICD-10): narrowly defined AN (F50.0), broadly defined AN (F50.0 + 50.1), narrowly defined BN (F50.2), and broadly defined BN (F50.2 + 50.3). The average annual percent changes (AAPCs) in incidence rates (IRs) were examined by Joinpoint regression analyses.Results: The overall (i.e., both genders, ages 10-49) rates of AN were stable across the 7-year period, with IRs ranging from 18.8 to 20.4 per 100,000 for narrowly defined AN and 33.2 to 39.5 per 100,000 for broadly defined AN, whereas overall rates of BN declined. Age-and gender-stratification revealed a significant average annual increase in AN (narrow and broad) among 10-to 14-year-old girls. The incidence of broadly defined AN also increased significantly among females aged 15-19 years between 2010 and 2012, before leveling off. Nearly universal declines in the incidence of narrowly and broadly defined BN among females occurred. IRs among males were stable and comparatively low, with no significant trends toward increasing or decreasing rates of AN or BN over time.Discussion: Although register-based studies provide an underestimate of the true incidence and may not accurately reflect population-level changes in true ED occurrence, this study extends our knowledge regarding trends in the detected incidence of EDs into the second decade of the 21st century. K E Y W O R D Sanorexia nervosa, bulimia nervosa, epidemiology, incidence, Joinpoint, time-trends The question of whether the incidence, or annual diagnostic rate, of anorexia nervosa (AN) and bulimia nervosa (BN) has increased over the past decades is a subject of debate. Long-term epidemiological data are valuable, yet challenging to obtain and interpret, and disposed to known methodological challenges (see Hart,

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The ups and downs of anorexia nervosa

Cited by 33 publications

References 0 publications

The effects of recombinant human parathyroid hormone, rhPTH(1-84), on bone mass in undernourished rats

The effects of recombinant human parathyroid hormone, rhPTH(1-84), on bone mass in undernourished rats

The Epidemic of Anorexia Nervosa: Myth or Reality?

Time trends in healthcare‐detected incidence of anorexia nervosa and bulimia nervosa in the Norwegian National Patient Register (2010–2016)

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