1987
DOI: 10.1002/j.1460-2075.1987.tb02708.x
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The upstream regulatory region of the human papilloma virus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones.

Abstract: The upstream regulatory region of the human papilloma virus‐16 (HPV‐16) genomic DNA contains a sequence element with a large degree of homology to the partially palindromic sequence GGTACANNNTGTTCT, which is the consensus sequence of the glucocorticoid responsive elements of known genes regulated by this steroid hormone. DNase I and dimethylsulfate protection experiments reveal the binding of this sequence by rat glucocorticoid receptor protein. A 400‐bp DNA segment centrally containing this sequence confers s… Show more

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Cited by 239 publications
(205 citation statements)
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References 59 publications
(83 reference statements)
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“…The growth on plastic of both cell lines became hormone independent at later passages, but the anchorage-independent growth was hormone dependent. Viral transcription is known to be positively regulated by glucocorticoid hormones via the up-stream regulatory region, which may at least partly explain its contributing effect to the transformation (Gloss et al, 1987;Mittal et al, 1993). …”
Section: Discussionmentioning
confidence: 99%
“…The growth on plastic of both cell lines became hormone independent at later passages, but the anchorage-independent growth was hormone dependent. Viral transcription is known to be positively regulated by glucocorticoid hormones via the up-stream regulatory region, which may at least partly explain its contributing effect to the transformation (Gloss et al, 1987;Mittal et al, 1993). …”
Section: Discussionmentioning
confidence: 99%
“…These types of cancers are typically preceded by clinically detectable premalignant, that is, noninvasive lesions that usually arise in epithelial transition zones where cell types are changing. The reasons for the restriction of HPV16-associated tumor development to certain anatomic sites are not clear, but epithelium-specific transcriptional activation of the HPV16 oncogenes (Cripe et al, 1987;Gloss et al, 1987) is likely to play a critical role. More people are infected with HPV16 and HPV18 than develop premalignant lesions and most individuals clear initial infections (IARC, 1995a).…”
Section: Introductionmentioning
confidence: 99%
“…The activity of this promoter is regulated by transcriptional control elements in the long control region (LCR), which is located upstream of the start site (Gloss et al, 1987). Several nuclear factors have been shown to bind the LCR at specific sites and regulate the transcriptional activity of the promoter, leading to keratinocyte-specific transcriptional activation of HPV.…”
Section: Introductionmentioning
confidence: 99%