The upstream stem–loop domain of the 3′ untranslated region of apolipoprotein II mRNA binds the estrogen-regulated mRNA stabilizing factor

Ratna, Warren N; Oyeamalu, Chioma

doi:10.1016/s0960-0760(02)00035-3

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Variations in length and sequence in the 3 0 untranslated region (UTR) can affect the localisation, longevity, stability, and translational efficiency of transcripts (Mazumder et al 2007;Mignone et al 2002;Ratna and Oyeamalu 2002;Schaaf and Cidlowski 2002;Wilkie et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)

et al. 2010

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Isoprene is a volatile 5-carbon hydrocarbon derived from the chloroplastic methylerythritol 2-C-methyl-D: -erythritol 4-phosphate isoprenoid pathway. In plants, isoprene emission is controlled by the enzyme isoprene synthase; however, there is still relatively little known about the genetics and regulation of this enzyme. Isoprene synthase gene structure was analysed in three poplar species. It was found that genes encoding stromal isoprene synthase exist as a small gene family, the members of which encode virtually identical proteins and are differentially regulated. Accumulation of isoprene synthase protein is developmentally regulated, but does not differ between sun and shade leaves and does not increase when heat stress is applied. Our data suggest that, in mature leaves, isoprene emission rates are primarily determined by substrate (dimethylallyl diphosphate, DMADP) availability. In immature leaves, where isoprene synthase levels are variable, emission levels are also influenced by the amount of isoprene synthase protein. No thylakoid isoforms could be identified in Populus alba or in Salix babylonica. Together, these data show that control of isoprene emission at the genetic level is far more complicated than previously assumed.

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Section: Discussionmentioning

confidence: 99%

Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)

et al. 2010

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“…The stability of the apo II mRNA has been shown to be primarily due to a factor, namely the estrogen-regulated mRNA stabilizing factor (E-RmRNASF), expressed in response to estrogen. E-RmRNASF binds to a specific motif in the 3’untranslated region of apo II mRNA to prevent nucleolytic degradation of the mRNA [5]. …”

Section: Introductionmentioning

confidence: 99%

Estrogen-responsive genes encoding egg yolk proteins vitellogenin and apolipoprotein II in chicken are differentially regulated by selective estrogen receptor modulators

et al. 2016

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In a hen, large quantities of the egg yolk proteins apolipoprotein (apo) II and vitellogenin (VG), are expressed in the liver and transported to the oviduct during egg production. Estrogenic stimulation of the hepatic expression of apo II and VG is due to both transcriptional increase and mRNA stabilization. The nucleolytic degradation of apo II mRNA is prevented by estrogen-regulated mRNA stabilizing factor (E-RmRNASF). Gene-specific effects of a select panel of SERMs on the hepatic expression of the estrogen-responsive genes encoding apo II, VG and E-RmRNASF in the chicken liver were investigated. In the present study, 6-week-old roosters were treated with the vehicle, estrogen, the SERMs genistein, resveratrol, tamoxifen, pterostilbene, raloxifene, catechin and clomiphene or a combination of estrogen and a 200-fold excess of each of the SERMs. Results from mRNA stabilization studies, conducted to investigate the stimulation of expression of E-RmRNASF in the liver by these agents showed that the expression of E-RmRNASF in the liver, was stimulated by estrogen, and the SERMs genistein, resveratrol, tamoxifen, pterostilbene, and catechin, but not by the vehicle, clomiphene or raloxifene. The expression of apo II and VG from the above treatments was determined by Northern blot analysis, RNase protection assays and Western blot analysis. The transcription and protein expression of both apo II and VG genes were seen in response to treatment with estrogen but not with the SERMs or combinations of estrogen and each of the SERMs. The SERMs that stimulated the expression of E-RmRNASF, antagonized the stimulation of the expression of both apo II and VG by estrogen, demonstrating a gene-specific, selective regulation of the above genes in the chicken liver by the SERMs. The above panel of SERMs may likely have adverse effects on egg production.

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“…This study was able to narrow the binding domain of E-RmRNASF to be between nts 402-548, within the 3 -UTR of apolipoprotein mRNA (Ratna and Oyeamalu 2002).…”

Section: Xv) An Endoribonuclease Capable Of Degrading Apolipoprotein mentioning

confidence: 94%

“…An estrogen-regulated mRNA stabilization factor (E-RmRNASF) has now also been identified and characterized, and is believed to act as a binding protein to protect apolipoprotein II mRNA from endonucleolytic degradation (Ratna and Oyeamalu 2002). This study was able to narrow the binding domain of E-RmRNASF to be between nts 402-548, within the 3 -UTR of apolipoprotein mRNA (Ratna and Oyeamalu 2002).…”

Section: Xv) An Endoribonuclease Capable Of Degrading Apolipoprotein mentioning

confidence: 95%

Characterization of a novel endoribonuclease capable of degrading c-myc mRNA in vitro.

Urquhart¹

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The upstream stem–loop domain of the 3′ untranslated region of apolipoprotein II mRNA binds the estrogen-regulated mRNA stabilizing factor

Cited by 6 publications

References 31 publications

Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)

Genetic structure and regulation of isoprene synthase in Poplar (Populus spp.)

Estrogen-responsive genes encoding egg yolk proteins vitellogenin and apolipoprotein II in chicken are differentially regulated by selective estrogen receptor modulators

Characterization of a novel endoribonuclease capable of degrading c-myc mRNA in vitro.

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