The uptake, effects and biotransformation of monepantel in meadow plants used as a livestock feed

Stuchlíková, Lucie Raisová; Jakubec, Pavel; Langhansová, Lenka; Podlipná, Radka; Navrátilová, Martina; Szotáková, Barbora; Skálová, Lenka

doi:10.1016/j.chemosphere.2019.124434

Cited by 9 publications

(7 citation statements)

References 27 publications

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“…So far, metabolites formed through glucuronidation are primarily known from animal studies [37]. There is only a single paper (published very recently) reporting (based on HPLC-MS data) the formation of glucuronic acid adducts in meadow plants treated with monopatel, a veterinary anthelmintic [37]. We were able to detect four DCF-based substances, where our data suggested a high probability for the presence of metabolites containing glucuronic acid.…”

Section: Detection Of Drug-related Metabolites In Nine Edible Plantsmentioning

confidence: 69%

“…Out of these transformation products, two are particularly exceptional. So far, metabolites formed through glucuronidation are primarily known from animal studies [37]. There is only a single paper (published very recently) reporting (based on HPLC-MS data) the formation of glucuronic acid adducts in meadow plants treated with monopatel, a veterinary anthelmintic [37].…”

Section: Detection Of Drug-related Metabolites In Nine Edible Plantsmentioning

confidence: 99%

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A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

Mlynek¹,

Himmelsbach²,

Buchberger³

et al. 2020

Anal Bioanal Chem

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Investigations into the interaction of xenobiotics with plants (and in particular edible plants) have gained substantial interest, as water scarcity due to climate-change-related droughts requires the more frequent use of reclaimed wastewaters for irrigation in agriculture. Non-steroidal anti-inflammatory drugs are common contaminants found in wastewater treatment plant effluents. For this reason, the interaction of nine edible plants with diclofenac (DCF), a widely used representative of this group of drugs, was investigated. For this purpose, plants were hydroponically grown in a medium containing DCF. For the detection of unknown DCF-related metabolites formed in the plant upon uptake of the parent drug‚ a new workflow based on the use of HPLC coupled to drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry (DTIM QTOF-MS) was developed. Thereby‚ for chromatographic peaks eluting from the HPLC, drift times were recorded, and analytes were subsequently fragmented in the DTIM QTOF-MS to provide significant fragments. All information available (retention times, drift times, fragment spectra, accurate mass) was finally combined‚ allowing the suggestion of molecular formulas for 30 DCF-related metabolites formed in the plant, whereby 23 of them were not yet known from the literature.

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Section: Detection Of Drug-related Metabolites In Nine Edible Plantsmentioning

confidence: 69%

Section: Detection Of Drug-related Metabolites In Nine Edible Plantsmentioning

confidence: 99%

A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

Mlynek¹,

Himmelsbach²,

Buchberger³

et al. 2020

Anal Bioanal Chem

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“…Contrary to ABZ, long-term exposition of Medicago sativa regenerants to monepantel did not change the proline accumulation, neither in the leaves nor the roots [8]. However, ivermectin increased the proline accumulation in a Plantago lanceolata cell suspension [19].…”

Section: Effect Of Abz On Proline Accumulation In Alfalfa Regenerantsmentioning

confidence: 78%

“…Fenbendazole also significantly affected gene and protein expression in A. thaliana plants [6]. Neither albendazole (ABZ) nor monepantel inhibited seed germination in Sinapis alba [7,8], but further information about their effects in plants is lacking. The phytotoxicity of other anthelmintics has not been studied yet [1].…”

Section: Introductionmentioning

confidence: 99%

The Identification of Metabolites and Effects of Albendazole in Alfalfa (Medicago sativa)

Stuchlíková

Navrátilová

Langhansová

et al. 2020

IJMS

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Albendazole (ABZ), a widely used anthelmintic drug, enters the environment mainly via livestock excrements. To evaluate the environmental impact of ABZ, the knowledge of its uptake, effects and metabolism in all non-target organisms, including plants, is essential. The present study was designed to identify the metabolic pathway of ABZ and to test potential ABZ phytotoxicity in fodder plant alfalfa, with seeds and in vitro regenerants used for these purposes. Alfalfa was chosen, as it may meet manure from ABZ-treated animals in pastures and fields. Alfalfa is often used as a feed of livestock, which might already be infected with helminths. The obtained results showed that ABZ did not inhibit alfalfa seed germination and germ growth, but evoked stress and a toxic effect in alfalfa regenerants. Alfalfa regenerants were able to uptake ABZ and transform it into 21 metabolites. UHPLC-MS/MS analysis revealed three new ABZ metabolites that have not been described yet. The discovery of the parent compound ABZ together with the anthelmintically active and instable metabolites in alfalfa leaves shows that the contact of fodder plants with ABZ-containing manure might represent not only a danger for herbivorous invertebrates, but also may cause the development of ABZ resistance in helminths.

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“…More than 80% of BIT and LEV remained in the surface soil layer, and the amount of the two target compounds in the leachates accounted for less than 1% of overall recovery. Stuchlíková et al (2019) studied the phytotoxicity, uptake, and biotransformation of the anthelmintic compound monepantel (MOP) in two fodder plants commonly used as a livestock feed, Plantago lanceolata and Medicago sativa, during 6 weeks of cultivation. MOP showed no phytotoxicity; however, both plants were able to uptake, transport, and metabolize the anthelmintic compound.…”

Section: Anthelminticsmentioning

confidence: 99%

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

Snow

Cassada

Biswas

et al. 2020

Water Environment Research

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A review of 79 papers published in 2019 is presented. The topics ranged from detailed descriptions of analytical methods, to fate and occurrence studies, to ecological effects and sampling techniques for a wide variety of emerging contaminants likely to occur in agricultural environments. New methods and studies on veterinary pharmaceuticals, antibiotics, anthelmintics, and engineered nanomaterials in agricultural environments continue to expand our knowledge base on the occurrence and potential impacts of these compounds. This review is divided into the following sections: Introduction, Analytical Methods, Antibiotics in Agroecosystems, Pharmaceutical Fate and Occurrence, Anthelmintics and Engineered Nanomaterials.

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The uptake, effects and biotransformation of monepantel in meadow plants used as a livestock feed

Cited by 9 publications

References 27 publications

A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

A new analytical workflow using HPLC with drift-tube ion-mobility quadrupole time-of-flight/mass spectrometry for the detection of drug-related metabolites in plants

The Identification of Metabolites and Effects of Albendazole in Alfalfa (Medicago sativa)

Detection, occurrence, and fate of emerging contaminants in agricultural environments (2020)

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