The Uptake of Plutonium in Bone Marrow: A Possible Leukaemic Risk

Vaughan, Janet; Bleaney, Betty; Williamson, Margaret

doi:10.1111/j.1365-2141.1967.tb00759.x

Cited by 23 publications

(3 citation statements)

References 14 publications

(13 reference statements)

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“…It is known that vertebrate lysosomes can sequester and concentrate metal ions including copper, mercury (and organic mercurials), lead, zinc, tellurium, iron, nickel, silver and plutonium (Koenig, 1963;Rahman & Lindenbaum, 1964;Scheuer, Thorpe & Marriott, 1967;Vaughan, Bleaney & Williamson, 1967;Verity & Reith, 1967;Barrett & Dingle, 1967;Abraham, Morris & Smith 1967;Slater, 1969;Brun & Brunk, 1970). Allison (1969) states that the accumulation of certain metal ions within lysosomes may labilize the membranes under certain conditions.…”

Section: Introductionmentioning

confidence: 99%

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

Moore

Stebbing

1976

J. Mar. Biol. Ass.

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(Plate I, The quantitative effects of Cu 8+ , Cd 2+ and Hg 2+ on the cytochemical staining reaction for lysosomal N-acetyl-/?-D-glucosaminidase have been determined and related to the inhibitory effects of the metals on colonial growth rate in the experimentally cultured hydroid Campanularia flexuosa. Cytochemical threshold concentrations are comparable to known environmental levels and are about one order of magnitude lower than those obtained by measuring colony growth rates.Pretreatment of colonies with Cu z+ gave no indication of tolerance adaptation, although there is evidence of the cumulative toxicity of Cu 2+ and the possible sequestration of this metal in endodermal cell lysosomes. There is also an indication that the Cu 2+ may exert its toxic effect by decreasing the stability of the lysosomal membranes, thus increasing the level of free glucosaminidase activity. INTRODUCTIONIt is known that vertebrate lysosomes can sequester and concentrate metal ions including copper, mercury (and organic mercurials), lead, zinc, tellurium, iron, nickel, silver and plutonium

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Section: Introductionmentioning

confidence: 99%

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

Moore

Stebbing

1976

J. Mar. Biol. Ass.

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“…The pattern of distribution of 239Pu in the marrow following the intravenous injection of 2 3 9 P~( N 0 3 ) 4 into both young and old rabbits and following intramuscular injection to old rabbits has already been described (Vaughan, Bleaney and Williamson, 1967;Bleaney, 1967Bleaney, , 1968). 239Pu is found in a diffuse distribution and in aggregates.…”

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confidence: 82%

A Study of ‘Haemosiderin’in the Marrow of the Femur of Normal Young Adult Rabbits Compared with that in Rabbits 4 Months after an Intravenous Injection of ²³⁹Pu(NO₃)₄

Beňo¹

1968

Br J Haematol

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A study of the distribution of cells containing iron, as demonstrated by Perls’reagent, in the marrow of the femur of normal young adult rabbits in comparison with that in rabbits of the same age group 4 months after an intravenous injection of 239Pu(NO3)4 is described. The number of iron containing cells, which are probably macrophages, was found to be variable in the length of the bone and also from one normal rabbit to another. The amount of pigment in any one cell was also variable. A significant increase in the number of iron containing cells and in the amount of pigment the cells contained was noted in the marrow of the femur of rabbits 4 months after a single intravenous injection of 239Pu(NO3)4, compared with the normal controls. 239Pu aggregates close to the mineralized surface were not characteristically associated with haemosiderin. This work was carried out at the Medical Research Council Unit for Research on Bone‐Seeking Isotopes, Oxford, while the author was holding a World Health Organization Fellowship. I am indebted to Dr. Janet Vaughan and Mrs. Betty Bleaney for much helpful advice and discussion. I also wish to thank Dr. David Taylor, Department of Biophysics, The Royal Cancer Hospital, for injecting the rabbits with 239Pu(NO3)4. I appreciate the technical help of Mr. John Halfacre.

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“…Plutonium is a "'bone-seeking'" actinide element which is concentrated from body fluids by bone surfaces [6,7] and by the surfaces of mineralized carti-Send q[l~rint request~ to N.D. Priest at the above address.…”

Section: Introductionmentioning

confidence: 99%

Uptake and loss of plutonium from osteoclasts and macrophages in the mandibular condyle of the rat

Priest¹,

Giannola²

1980

Calcif Tissue Int

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Female rats were used to study the kinetics of plutonium transfer from the bone surfaces of the mandibular condyle to osteoclasts and macrophages. This study was made using autoradiographs prepared from plastic sections of the mineralized bones of animals which had been injected with 241 Pu citrate. Measurements of the concentration of plutonium in the osteoclasts and macrophages at different times after the injection of plutonium showed that plutonium was concentrated by osteoclasts from bone surfaces and was retained with a half-time of approximately 70 h. Subsequently, plutonium appeared to be transferred to macrophages. The results showed that plutonium was unlikely to be accumulated by macrophages as a result of their participation in bone resorption.

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The Uptake of Plutonium in Bone Marrow: A Possible Leukaemic Risk

Cited by 23 publications

References 14 publications

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

A Study of ‘Haemosiderin’in the Marrow of the Femur of Normal Young Adult Rabbits Compared with that in Rabbits 4 Months after an Intravenous Injection of ²³⁹Pu(NO₃)₄

Uptake and loss of plutonium from osteoclasts and macrophages in the mandibular condyle of the rat

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The Uptake of Plutonium in Bone Marrow: A Possible Leukaemic Risk

Cited by 23 publications

References 14 publications

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

The quantitative cytochemical effects of three metal ions on a lysosomal hydrolase of a hydroid

A Study of ‘Haemosiderin’in the Marrow of the Femur of Normal Young Adult Rabbits Compared with that in Rabbits 4 Months after an Intravenous Injection of 239Pu(NO3)4

Uptake and loss of plutonium from osteoclasts and macrophages in the mandibular condyle of the rat

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A Study of ‘Haemosiderin’in the Marrow of the Femur of Normal Young Adult Rabbits Compared with that in Rabbits 4 Months after an Intravenous Injection of ²³⁹Pu(NO₃)₄