“…The family 1 UDGs, also known as Ung, excise U from both ssDNA and dsDNA, and possess two highly conserved sequences, GQDPY (motif A) and HPSPLS (motif B) (Krokan et al, 1997). Family 5 UDGs, also known as UdgB, are restricted to a limited number of organisms that survive in extreme habitats (Sartori et al, 2002;Starkuviene & Fritz, 2002;Wanner et al, 2009), excise uracil from dsDNA and possess conserved sequences, GLAPA and HPSPLNV (HPSQQN in M. tuberculosis) as motif A and motif B, respectively. In addition to uracil, the UdgB proteins excise 5-hydroxymethyl-uracil, ethenocytosine, 5-fluorouracil and Hx from dsDNA (Srinath et al, 2007;Sartori et al, 2002).…”