The urgent need for integrated science to fight COVID-19 pandemic and beyond

Moradian, Negar; Ochs, Hans D.; Sedikies, Constantine; Hamblin, Michael R.; Camargo, Carlos A.; Martínez, J. Alfredo; Biamonte, Jacob; Abdollahi, Mohammad; Torres, Pedro J.; Nieto, Juan J.; Ogino, Shuji; Seymour, John F.; Abraham, Ajith; Cauda, Valentina; Gupta, Sudhir; Ramakrishna, Seeram; Sellke, Frank W.; Sorooshian, Armin; Hayes, A. Wallace; Martínez-Urbistondo, María; Gupta, Manoj; Azadbakht, Leila; Esmaillzadeh, Ahmad; Kelishadi, Roya; Esteghamati, Alireza; Emam‐Djomeh, Zahra; Majdzadeh, Reza; Palit, Partha; Badali, Hamid; Rao, Idupulapati M.; Saboury, Ali Akbar; Rao, L. Jagan Mohan; Ahmadieh, Hamid; Montazeri, Ali; Fadini, Gian Paolo; Pauly, Daniel; Thomas, Sabu; Moosavi-Movahed, Ali A.; Aghamohammadi, Asghar; Behmanesh, Mehrdad; Rahimi-Movaghar, Vafa; Ghavami, Saeid; Mehran, Roxana; Uddin, Lucina Q.; Herrath, Matthias von; Mobasher, Bahram; Rezaei, Nima

doi:10.1186/s12967-020-02364-2

Cited by 159 publications

(124 citation statements)

References 55 publications

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“…COVID-19 has continued human-to-human transmission regardless of the triad of knowledge (both professional and nonprofessional) (Moazzami et al 2020), biological factors (both men and women), and the physiological condition (Mirbeyk and Rezaei 2020;Saghazadeh and Rezaei 2020a). In such critical time, it is not difficult to remember the previous pandemics (Jabbari et al 2020), though none of the lessons learned could be satisfactory, revealing with the COVID-19 pandemic the limitation of national strategies and the need for reliable research and international collaboration (Kafieh et al 2020;Mohamed et al 2020a;Momtazmanesh et al 2020;Moradian et al 2020;Rzymski et al 2020). After the six-month effort, there is a lack of specific treatment and vaccine, though numerous efforts have taken place to find potential therapeutic and preventive options (Moazzami et al 2020;Rabiee et al 2020;Yazdanpanah et al 2020) from repurposing drugs (Mohamed et al 2020b) and the design and manufacturing of antibodies (Jahanshahlu and Rezaei 2020b) to the development of cell-based therapies (Basiri et al 2020).…”

Section: Resultsmentioning

confidence: 99%

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

Yazdanpanah

Saghazadeh

Rezaei

2020

Reviews in the Neurosciences

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Just before 2020 began, a novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), brought for humans a potentially fatal disease known as coronavirus disease 2019 (COVID-19). The world has thoroughly been affected by COVID-19, while there has been little progress towards understanding the pathogenesis of COVID-19. Patients with a severe phenotype of disease and those who died from the disease have shown hyperinflammation and were more likely to develop neurological manifestations, linking the clinical disease with neuroimmunological features. Anosmia frequently occurs early in the course of COVID-19. The prevalence of anosmia would be influenced by self-diagnosis as well as self-misdiagnosis in patients with COVID-19. Despite this, the association between anosmia and COVID-19 has been a hope for research, aiming to understand the pathogenesis of COVID-19. Studies have suggested differently probable mechanisms for the development of anosmia in COVID-19, including olfactory cleft syndrome, postviral anosmia syndrome, cytokine storm, direct damage of olfactory sensory neurons, and impairment of the olfactory perception center in the brain. Thus, the observation of anosmia would direct us to find the pathogenesis of COVID-19 in the central nervous system, and this is consistent with numerous neurological manifestations related to COVID-19. Like other neurotropic viruses, SARS-CoV-2 might be able to enter the central nervous system via the olfactory epithelium and induce innate immune responses at the site of entry. Viral replication in the nonneural olfactory cells indirectly causes damage to the olfactory receptor nerves, and as a consequence, anosmia occurs. Further studies are required to investigate the neuroimmunology of COVID-19 in relation to anosmia.

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Section: Resultsmentioning

confidence: 99%

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

Yazdanpanah

Saghazadeh

Rezaei

2020

Reviews in the Neurosciences

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“…The biggest obstacle still is the quality of the internet connection, which research institutions should provide to their employees. (24). A recent OECD report (25) points out to the need to adopt a transdisciplinary attitude towards scientific research, given the complex nature of the societal challenges we are facing.…”

Section: Emerging Standards For the Hybrid Modelmentioning

confidence: 99%

Emerging Standards and the Hybrid Model for Organizing Scientific Events During and After the COVID-19 Pandemic

Hanaei

Takian

Majdzadeh

et al. 2020

Disaster med. public health prep.

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Since the beginning of 2020, the COVID-19 pandemic has dramatically influenced almost every aspect of human life. Activities requiring human gatherings have either been postponed, cancelled, or held completely virtually. To supplement lack of in-person contact, people have increasingly turned to virtual settings on-line, advantages of which include increased inclusivity and accessibility and reduction of carbon footprint. However, emerging online technologies cannot fully replace, in-person scientific events. In-person meetings are not susceptible to poor internet connectivity problems, and they provide novel opportunities for socialization, creating new collaborations, and sharing ideas. To continue such activities, a hybrid model for scientific events could be a solution offering both in-person and virtual components. While participants can freely choose the mode of their participation, virtual meetings would most benefit those who cannot attend in-person due to the limitations. In-person portions of meetings should be organized with full consideration of prevention and safety strategies including risk assessment and mitigation, venue and environmental sanitation, participant protection and disease prevention, and promoting the hybrid model. This new way of interaction between scholars can be considered as a part of a resilience system which was neglected previously and should become a part of routine practice in scientific community.

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“…It is known from other pandemics, such as the Spanish flu ( [11,12]) or the swine flu, that the development of the number of infected people looks like a Gaussian curve. The interesting points in time are those where the acceleration of the numbers of infected people increases or decreases, respectively.…”

Section: Looking For Other Strategies Of a Temporary Lockdowns And Exmentioning

confidence: 99%

Mathematical Modeling and Simulation of the COVID-19 Pandemic

Bärwolff

2020

Systems

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The current pandemic is a great challenge for several research areas. In addition to virology research, mathematical models and simulations can be a valuable contribution to the understanding of the dynamics of the pandemic and can give recommendations to physicians and politicians. Based on actual data of people infected with COVID-19 from the European Center for Disease Prevention and Control (ECDC), input parameters of mathematical models will be determined and applied. These parameters will be estimated for the UK, Italy, Spain, and Germany and used in an S I R -type model. As a basis for the model’s calibration, the initial exponential growth phase of the COVID-19 pandemic in the named countries is used. Strategies for the commencing and ending of social and economic shutdown measures are discussed.

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The urgent need for integrated science to fight COVID-19 pandemic and beyond

Cited by 159 publications

References 55 publications

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

Anosmia: a missing link in the neuroimmunology of coronavirus disease 2019 (COVID-19)

Emerging Standards and the Hybrid Model for Organizing Scientific Events During and After the COVID-19 Pandemic

Mathematical Modeling and Simulation of the COVID-19 Pandemic

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