The Usages and Potential Uses of Alginate for Healthcare Applications

Mollah, M.Z.I.; Zahid, Hasan M.; Mahal, Zinat; Faruque, Mohammad Rashed Iqbal; Khandaker, Mayeen Uddin

doi:10.3389/fmolb.2021.719972

Cited by 35 publications

(22 citation statements)

References 114 publications

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“…Alginate lacks the biomimetic characteristics of collagen‐based hydrogels, despite the fact that it can be useful for different biomedical applications. [ 34 ] Finally, contrary to GelMa, type I collagen hydrogels do not require external crosslinkers or catalysts that can potentially alter the biological response of cells. In the case of experiments involving type I collagen hydrogels and spheroids, samples can be mixed with an unpolymerized matrix solution and then deposited on top of a previously polymerized matrix layer or can also be suspended entirely inside a matrix without any underlying bed.…”

Section: Introductionmentioning

confidence: 99%

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration

Castro-Abril

Heras

Barrio

et al. 2023

Macromolecular Bioscience

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Mechanical interactions between cells and their microenvironment play an important role in determining cell fate, which is particularly relevant in metastasis, a process where cells invade tissue matrices with different mechanical properties. In vitro, type I collagen hydrogels have been commonly used for modeling the microenvironment due to its ubiquity in the human body. In this work, the combined influence of the stiffness of these hydrogels and their ultrastructure on the migration patterns of HCT‐116 and HT‐29 spheroids are analyzed. For this, six different types of pure type I collagen hydrogels by changing the collagen concentration and the gelation temperature are prepared. The stiffness of each sample is measured and its ultrastructure is characterized. Cell migration studies are then performed by seeding the spheroids in three different spatial conditions. It is shown that changes in the aforementioned parameters lead to differences in the mechanical stiffness of the matrices as well as the ultrastructure. These differences, in turn, lead to distinct cell migration patterns of HCT‐116 and HT‐29 spheroids in either of the spatial conditions tested. Based on these results, it is concluded that the stiffness and the ultrastructural organization of the matrix can actively modulate cell migration behavior in colorectal cancer spheroids.

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Section: Introductionmentioning

confidence: 99%

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration

Castro-Abril

Heras

Barrio

et al. 2023

Macromolecular Bioscience

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“…Additionally, antibiotic distribution in wound dressings is greatly influenced by the structural activity of the scaffold. The ability of the alginates to be changed or converted into biomaterials like hydrogels, wafers, fibers, biofilms, and foams helps to maintain a moist environment and to speed up the healing of wounds [ 86 ].…”

Section: Polysaccharides In Tissue Engineeringmentioning

confidence: 99%

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

et al. 2023

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Biological macromolecules like polysaccharides/proteins/glycoproteins have been widely used in the field of tissue engineering due to their ability to mimic the extracellular matrix of tissue. In addition to this, these macromolecules are found to have higher biocompatibility and no/lesser toxicity when compared to synthetic polymers. In recent years, scaffolds made up of proteins, polysaccharides, or glycoproteins have been highly used due to their tensile strength, biodegradability, and flexibility. This review is about the fabrication methods and applications of scaffolds made using various biological macromolecules, including polysaccharides like chitosan, agarose, cellulose, and dextran and proteins like soy proteins, zein proteins, etc. Biopolymer-based nanocomposite production and its application and limitations are also discussed in this review. This review also emphasizes the importance of using natural polymers rather than synthetic ones for developing scaffolds, as natural polymers have unique properties, like high biocompatibility, biodegradability, accessibility, stability, absence of toxicity, and low cost.

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“…The interaction of alginate with TLR4 is dependent on the molecular weight, monosaccharide composition, glycosidic bonds, functional groups, and branched-chain structure of polysaccharides. [215][216][217][218].…”

Section: Alginatementioning

confidence: 99%

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

Elango,

Zamora-Ledezma,

Maté-Sánchez de Val

2023

J. Compos. Sci.

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Modern research has evolved several approaches toward skin regeneration and one of the novel concerns is the use of polymer-based systems due to their excellent beneficial properties to the skin. Several polymers, such as cellulose, hyaluronan, alginate, chitosan, collagen, fibrin and fibroin, have been tested and have proven the benefits for skin regeneration, and most of them are derived from either polysaccharide- or protein-based materials. In order to understand the mode of action, several researchers investigated the cell–matrix interaction and possible signaling mechanism in skin regeneration. Not only the signaling mechanism but also the mode of cell communication determines the application of polysaccharide- and protein-based polymers in practice. Based on the above significance, this review disclosed the recent findings to compile a possible method of communication between cells and polymers derived from polysaccharide-based (such as cellulose, hyaluronan, chitosan, alginate, agar, and xanthan gum) and protein-based (such as collagen, gelatin, fibrin, and silk fibroin) materials along with other polymers, such as poly(vinyl alcohol), polyglycolide or poly(glycolic acid), or poly(lactic acid) in skin regeneration. Accordingly, this review addresses the fundamental concept of cell–matrix communication, which helps us to understand the basis of the polymer’s functions in the biomedical field.

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The Usages and Potential Uses of Alginate for Healthcare Applications

Cited by 35 publications

References 114 publications

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration

The Role of Mechanical Properties and Structure of Type I Collagen Hydrogels on Colorectal Cancer Cell Migration

Scaffold Using Chitosan, Agarose, Cellulose, Dextran and Protein for Tissue Engineering—A Review

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

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