The USAID/Government of Egypt's Schistosomiasis Research Project (SRP)

Khoby, Taha El; Galal, N.; Fenwick, Alan

doi:10.1016/s0169-4758(97)01206-4

Cited by 58 publications

(41 citation statements)

References 11 publications

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“…For example, all school-age children and millions of adults are screened and, if necessary, treated every 6 to 12 months in Egypt. In high-prevalence areas, treatment is now given indiscriminately to the entire population (46). Out of concern for the appearance of drug resistance under such high drug pressure, an elaborate national monitoring system has been set up in which stool samples from apparent treatment failures are referred to regional research centers and subjected to in vivo and in vitro tests.…”

Section: Drug Resistance In Schistosomesmentioning

confidence: 99%

“…A nationwide monitoring system was set up to detect and investigate cases in which PZQ did not lead to cure, even after repeated treatment (9,46). From several dozen cases, largely clustered in one geographical area, parasites were isolated that showed a reduced susceptibility in mice and in vitro compared to Egyptian reference strains (10, 81, 81a).…”

Section: Drug Resistance In Schistosomesmentioning

confidence: 99%

“…Two IVM treatments per year for a period of at least 10 years are recommended to interrupt transmission of O. volvulus among humans (156). In countries such as Egypt, active antischistosomal community treatment with PZQ has been going on for more than a decade already and will be continued, even intensified, for the foreseeable future (46). AR probably will not develop as easily in helminths with an indirect life cycle (having the multiplicative part of their cycle in arthropods or molluscs) as in directly transmissible intestinal helminths.…”

Section: Contributing Factors For the Development Of Resistancementioning

confidence: 99%

See 2 more Smart Citations

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Geerts

Gryseels

2000

Clinical Microbiology Reviews

231

130

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Section: Drug Resistance In Schistosomesmentioning

confidence: 99%

Section: Drug Resistance In Schistosomesmentioning

confidence: 99%

Section: Contributing Factors For the Development Of Resistancementioning

confidence: 99%

See 1 more Smart Citation

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Geerts

Gryseels

2000

Clinical Microbiology Reviews

231

130

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“…Snail control strategies are considered a priority of the reduction of schistosomiasis transmission. Although the use of molluscicides has always been considered a major supportive procedure in integrated schistosomiasis control, yet, there are gaining increased attention for newly molluscicides, as they may be highly effective, rapidly biodegradable, less expensive than synthetic molluscicides and probably easily applicable with simple techniques (El-Khoby et al, 1998).…”

Section: Control Of Snail Intermediate Hosts Remains An Essential Commentioning

confidence: 99%

Antischistosomal impact of Albendazole and Nitazode on Schistosoma mansoni larval stages

El-Enain¹,

Sharaf²,

S³

2015

Afr. J. Microbiol. Res.

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Albendazole and Nitazode were tested as molluscicidal agents against Biomphalaria alexandrina snails. The effect of Albendazole and Nitazode on snails infected with Schistosoma mansoni miracidia and hermaphrodite glands of Biomphalaria alexandrina snails were also carried out. In addition, the parasitological parameters, the dynamics of serum-specific immunoglobulins and splenic cytokines associated with changes in granuloma diameter were assessed. The results indicate that exposure of B. alexandrina to Albendazole and Nitazode, resulted in a considerable reduction in the infectivity of S. mansoni miracidia to the snails and a severe damage in the hermaphrodite gland cells of treated snails. In addition, immunization did not affect worm reduction, but a slight decrease in granuloma diameter, increase in immunoglobulins and cytokines was observed. Reduction in worm burden was associated with a reduction in ova count. Changes in oogram pattern were mainly due to Albendazole and Nitazode. In conclusion, treatment with Albendazole and Nitazode with immunization resulted in significant reduction of parasitological parameters and rise of specific immunoglobulins.

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“…In all, mass treatment turned out to be more effective than mass screening. It was also made much more palatable after the development of a paediatric suspension of praziquantel suitable for young children and others unable to swallow the large and very bitter tablet formulation [17].…”

Section: The Modern Era Of Infection Controlmentioning

confidence: 99%

Successful control of schistosomiasis and the changing epidemiology of bladder cancer in Egypt

et al. 2010

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What’s known on the subject? and What does the study add? The association between squamous cell carcinoma of the bladder and schistosomal bladder infection is well‐known to most physicians. Less recognized is the remarkable cause and effect relationship between the eradication of schistosomiasis and the subsequent radical decline in squamous cell bladder cancer. Public health initiatives in Egypt have effectively eliminated the most common cause of death in young Egyptian men, and the result is a testament to how basic science, properly applied to public policy, can dramatically improve the health of an entire country. Schistosomiasis is a parasitic disease caused by flatworms that live in snail‐infested fresh water. It is endemic to 74 countries and affects some 200 million people worldwide, causing an estimated 200 000 deaths annually [1]. Schistosomiasis can affect the gastrointestinal tract and liver (S. mansoni and S. japonicum species), resulting in diarrhoeal disease and hepatic fibrosis, or the urinary tract (S. haematobium) where it causes haematuria, strictures, obstruction, super‐infection and, ultimately, cancer. In children and vulnerable adults, systemic effects such as anaemia, malnutrition, stunted growth and impaired cognition can be profound. The association between this parasitic infestation and the development of bladder cancer literally took millennia to uncover. It is unusual for a parasitic disease to result in a fatal neoplastic process, and rarer still to have public health efforts, aimed at eradication of the parasitic menace, to result in a dramatic shift in the epidemiology of the most common cancer in a nation.

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The USAID/Government of Egypt's Schistosomiasis Research Project (SRP)

Cited by 58 publications

References 11 publications

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Drug Resistance in Human Helminths: Current Situation and Lessons from Livestock

Antischistosomal impact of Albendazole and Nitazode on Schistosoma mansoni larval stages

Successful control of schistosomiasis and the changing epidemiology of bladder cancer in Egypt

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