Tuberculosis (TB) remains a global problem up to this day. Against the background of the successes achieved in the fight against this infection, many problems have not yet been fully solved. These problems include drug resistance of the pathogen, comorbidity and multimorbidity of TB, the search for new types of drugs, the management and prevention of undesirable side effects of longterm chemotherapy, etc. These problems can only be solved through collaboration between health care professionals and patients. Timely abacillation, closing of decay cavities and stabilization of the clinical condition are practically impossible without such cooperation. Therefore, an important task of phthisiology is to stabilize the patient’s adherence to antiTB therapy throughout the course of treatment.The aim of the review is to describe existing and innovative ways to improve the level of adherence of TB patients to antiTB therapy.Conclusion. Current methods to improve adherence of TB patients, both in Russia and other countries, need to be improved and adequately funded. Additive technologies that more effectively reduce the risks of unmotivated discontinuation of polychemotherapy may be the solution.