Objective: A prospective cohort study was conducted to
investigate sleep status during the first and second trimester of
pregnancy in pregnant women on adverse birth outcome, such as preterm
birth (PTB), low birth weight (LBW) and small for gestational age (SGA).
Design: Prospective cohort study. Setting: China.
Population: Cases were singleton pregnant women aged 18-40
years from the prospective Tongji-Shuangliu Birth Cohort.
Methods: Multivariable logistic regression models were used to
analyze the associationof sleep status during the first and second
trimester of pregnancy with adverse birth outcomes and generated the
odds ratio (OR) and 95% confidence interval (CI). Main outcome
measures: Birth outcomes. Results: Finally, 5,412 pregnant
women were included in the analysis. In the multivariable model,
compared with 8-9 hours/night, sleep less than 7 hours/night during
second trimester increases the risk of PTB (OR: 1.80, 95% CI:
1.12,2.89), and the risk of PTB was decreased in pregnant women who
slept ≥11 hours/night (OR: 0.53, 95% CI: 0.30,0.93). Sleep quality,
napping and sleep changes in the first and second trimesters, and sleep
duration in the first trimester were not statistically associated with
PTB, LBW and SGA. Conclusions: Short sleep duration during
pregnancy is associated with a higher risk of PTB, while longer sleep
duration at night is associated with a lower risk of PTB. Sleep status
during pregnancy was not associated with LBW and SGA. In order to reduce
risk of adverse birth outcomes, sleep problems in pregnant women should
be strengthened during pregnancy care.