The use of a cation-exchange resin in the determination of some basic substances (tyrosine, tyramine, kynurenine, 3-hydroxykynurenine and cystine) in urine

Tompsett, S. L.

doi:10.1016/0009-8981(62)90115-8

Cited by 5 publications

(1 citation statement)

References 7 publications

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“…water and 0-5 ml. concentrated HUl, and was chromatographed on a Dowex 50 (H+ form) column by a modification of the method of Tompsett (1962). Aliquots of the eluate were assayed as above (Table 1).…”

Section: Methodsmentioning

confidence: 99%

Hormone‐induced modifications of free tyrosine in the rat thyroid gland

Hodge¹,

Melmon²,

Sjoerdsma³

1969

The Journal of Physiology

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SUMMARYThe concentrations of free tyrosine in liver, muscle, kidney and thyroid gland were determined in separate groups of rats maintained on a low iodine diet and treated with intraperitoneal iiijections of thyroxine (T 4), thyrotrophin (TSH) and TSH plus propylthiouracil (PTU). Groups of hypophysectomized rats also were given T 4. Significant changes in tissue tyrosine were generally confined to the thyroid gland. Animals treated with T 4 showed a decrease of mean thyroid tyrosine from 113-3 + 17-9 (S.D.) /sg/g wet weight of gland to 76 2 + 5*7 ,ug/g (P < 0-01). Although there was little change in content when TSH was given alone, a significant increase in tyrosine levels was observed when TSH plus PTU were administered (P < 0-01). In hypophysectomized rats thyroid tyrosine decreased and was further lowered (to 46-0 + 3-1 ,tg/g; P < 0.05) by T 4 treatment.When tyrosine concentrations were expressed in relation to ribonucleic acid (RNA) or protein content of the assayed gland, all differences in tyrosine content became greater.

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Section: Methodsmentioning

confidence: 99%