The use of a collagen matrix in hard-to-heal venous leg ulcers

Romanelli, Marco; Mulder, Gerit; Paggi, Battistino; Macchia, Michela; Panduri, Salvatore; Dini, Valentina

doi:10.12968/jowc.2015.24.11.543

Cited by 17 publications

(11 citation statements)

References 11 publications

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“…Collagen-based wound dressings (including partially purified skin, hydrolyzed collagen and collagen sponge, fiber, powder or composite dressings) have been shown to have practical and economic advantages over growth-factor and cell-based dressings in the treatment of full-thickness wounds [ 45 ]. Several studies have shown the advantage of collagen dressings compared to the standard of care [ 46 , 47 , 48 , 49 ] and alginate dressings [ 45 , 50 ]. Adding a collagen dressing to the standard of care protocol has been shown to increase the probability of ulcer healing from 0.11 to 0.49 by 6 months and may reduce management costs by 40% [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study

Mościcka

Cwajda‐Białasik

Szewczyk

et al. 2022

IJERPH

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The aim of the study was to assess the effectiveness of fish skin collagen and its impact on healing, pain intensity, and quality of life in patients with venous leg ulcers (VLUs). This study included 100 adults with VLUs. Eligible patients were randomized to either tropocollagen gel treatment (group A, n = 47) or placebo alone (group B, n = 45). We applied the gel to the periwound skin for 12 weeks. All groups received standard wound care, including class 2 compression therapy and wound hygiene procedures. We assessed the healing rate (cm2/week) and quality of life (QoL) using the Skindex-29 and CIVIQ scales. In group A, more ulcers healed, and the healing rate was faster. In both study groups, patients showed a significant improvement in quality of life after the intervention, but there was a greater improvement in the tropocollagen group. In group A, the greatest improvement was related to physical symptoms and the pain dimension. This study showed that the application of fish collagen gel to the periwound skin improves the healing process and QoL in patients with VLUs. The 12-week treatment with collagen reduced the severity of physical complaints, pain, and local skin symptoms, which determined the quality of life in patients with VLUs to the greatest extent.

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Section: Discussionmentioning

confidence: 99%

Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study

Mościcka

Cwajda‐Białasik

Szewczyk

et al. 2022

IJERPH

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“…The basic characteristics of the included studies are described in Table 1, and the wound characteristics are described in Table 2 (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). A total of 961 patients, of whom 485 were in the collagen group, were enrolled in this study.…”

Section: Study Characteristicsmentioning

confidence: 99%

The clinical efficacy of collagen dressing on chronic wounds: A meta-analysis of 11 randomized controlled trials

et al. 2022

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ObjectiveThis study aims to evaluate the clinical efficacy of collagen dressing for patients with chronic wounds.Materials and methodsRelevant randomized controlled trials were searched from the databases such as PubMed, EMBASE, and the Cochrane library as of January 2022. For dichotomous outcomes and continuous outcomes, risk ratio and mean difference were calculated, respectively. Subgroup analysis was performed according to the type of chronic ulcer and follow-up. In addition, trial sequential analysis (TSA) was performed to further verify the results. Jadad score was used to assess the quality of trials. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was utilized to assess the level of evidence for outcomes.ResultsIn 11 studies, a total of 961 patients of whom 485 were in the collagen group. Compared with standard of care (SOC) alone, the group that added an extra collagen dressing achieved a higher wound healing rate (Risk Ratio = 1.53; 95% CI, 1.33–1.77). The collagen group also showed a higher healing velocity than the SOC group (Mean Difference, 2.69; 95% CI, 0.87–4.51). In addition, the adverse events related to dressing between the two groups were similar (Risk Ratio = 0.67; 95% CI, 0.44–1.01).ConclusionCollagen dressing increases the wound healing rate and may be an effective and safe treatment for chronic wound management. However, more extensive research shall be conducted to substantiate these results.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=245728, identifier: CRD42021245728.

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“…Together with its biocompatibility, biodegradable, and non-toxic attributes, these advantages make collagen an attractive candidate material for treating recalcitrant wounds. Numerous clinical studies highlight the benefit of collagen-based dressings for treating chronic wounds, showing faster healing rates or shorter healing times, inactivation of proteases and maintenance of moist wound environment [69][70][71][72].…”

Section: Collagen Dressingsmentioning

confidence: 99%

Wound dressings: curbing inflammation in chronic wound healing

Verdolino

Thomason

Fotticchia

et al. 2021

Emerging Topics in Life Sciences

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Chronic wounds represent an economic burden to healthcare systems worldwide and a societal burden to patients, deeply impacting their quality of life. The incidence of recalcitrant wounds has been steadily increasing since the population more susceptible, the elderly and diabetic, are rapidly growing. Chronic wounds are characterised by a delayed wound healing process that takes longer to heal under standard of care than acute (i.e. healthy) wounds. Two of the most common problems associated with chronic wounds are inflammation and infection, with the latter usually exacerbating the former. With this in mind, researchers and wound care companies have developed and marketed a wide variety of wound dressings presenting different compositions but all aimed at promoting healing. This makes it harder for physicians to choose the correct therapy, especially given a lack of public quantitative data to support the manufacturers’ claims. This review aims at giving a brief introduction to the clinical need for chronic wound dressings, focusing on inflammation and evaluating how bio-derived and synthetic dressings may control excess inflammation and promote healing.

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The use of a collagen matrix in hard-to-heal venous leg ulcers

Abstract: The results of this study showed the effectiveness and safety of a collagen dressing in hard-to-heal vlUs as an adjunctive therapy with compression bandaging. These encouraging results may positively affect the quality of life of patients with chronic wounds.

Cited by 17 publications

References 11 publications

Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study

Healing Process, Pain, and Health-Related Quality of Life in Patients with Venous Leg Ulcers Treated with Fish Collagen Gel: A 12-Week Randomized Single-Center Study

The clinical efficacy of collagen dressing on chronic wounds: A meta-analysis of 11 randomized controlled trials

Wound dressings: curbing inflammation in chronic wound healing

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