The Use of a Decision Tree Based on the Rabies Diagnosis Scenario, to Assist the Implementation of Alternatives to Laboratory Animals

Bones, Vanessa Carli; Molento, Carla Forte Maiolino

doi:10.1177/026119291604400201

Cited by 3 publications

(4 citation statements)

References 10 publications

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“…Additionally, transparency in terms of the numbers used also permits the recognition by society of those laboratories that are working towards animal replacement. 18…”

Section: Resultsmentioning

confidence: 99%

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Factors Related to Animal Neglect in Brazilian Laboratories

Bones

Molento

2020

Altern Lab Anim

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Our objectives were to identify the prevalence of negligence of laboratory animals in Brazil, to determine the primary factors associated with its occurrence and to suggest prevention strategies. A questionnaire was made available online between October 2015 and March 2016. A total of 116 respondents with experience in the use of laboratory animals and/or the use of alternative methods answered the questionnaire. Most respondents were women (77 respondents, 66.4%), a significant proportion had a degree in Veterinary Medicine (31 respondents, 27.2%), and a majority used animals in their work (88 respondents, 75.9%). Of the 88 animal users, 23 supplied information on the numbers and species of animals they used. When asked whether they knew that Brazilian law forbade animal experimentation when alternative methods exist, seven (9.1%) respondents mentioned Act 9605/1998. Most, but not all, respondents (96 respondents, 82.8%) submitted their projects to an Animal Use and Ethics Committee (AUEC), and many (65 respondents, 56%) reported their belief that animal neglect occurred at their institution. Negligence was found to be associated with: institutions where the numbers of animals used were not recorded ( p = 0.008); institutions where respondents were unaware of the relevant legislation, that is, Act 9605/1998 ( p = 0.042); or where there was evidence that not all project proposals were submitted to the AUEC or evidence of no submissions at all ( p = 0.022). Negligence of animals was found to be highly prevalent. Prevention strategies might involve increased transparency to the general public, the empowerment of individuals that work with animals to report any concerns, optimised inspection of facilities where animal work is carried out and significant improvements to the role of AUECs.

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“…Additionally, transparency in terms of the numbers used also permits the recognition by society of those laboratories that are working towards animal replacement. 18…”

Section: Resultsmentioning

confidence: 99%

“…34 Furthermore, transparency allows the recognition of laboratories that are implementing alternative methods and facilitates further financial support to develop such methods. 18…”

Section: Resultsmentioning

confidence: 99%

Factors Related to Animal Neglect in Brazilian Laboratories

Bones

Molento

2020

Altern Lab Anim

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“…The CRT growing method was used to maximize within-node homogeneity. CRT split the data into segments that were as homogeneous as possible with respect to the dependent variable (31,32).…”

Section: Discussionmentioning

confidence: 99%

Obesity, lifestyle behaviors and dyslipidemia among Chinese adults aged 45 and older

Liu

You

Meng

et al. 2019

Preprint

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BackgroundThis study investigated the importance of obesity and lifestyle behaviors in affecting dyslipidemia among adults aged 45 and older in China. The strength of our study is in using the decision tree model to clearly rank the importance of those key factors affecting dyslipidemia. MethodsData were taken from the China Health and Retirement Longitudinal Study. A total of 9,038 adults were included in the study. Logistic regression was used to examine the associations between obesity, lifestyle behaviors and dyslipidemia. Decision tree was built to select the best scheme on prevention of dyslipidemia. ResultsBased on body mass index (BMI), 33.98% of Chinese age ≥ 45 years old were overweight and a further 12.73% were obese. Logistic regression analysis showed that participants who were obese (AOR 6.82, 95% CI 3.67-12.37, P<0.0001), with hypertension stage 2 (1.53, 1.23-1.90, P=0.0001) and lived in main city zone (2.68, 2.22-3.22, P<0.0001) were more likely to have dyslipidemia; Participants who usually took part in vigorous activity (0.66, 0.54-0.80, P<0.0001) or did moderate/light activity more than 2 hours one day (moderate: 0.66, 0.53-0.84, P=0.0005; light: 0.79, 0.65-0.97, P=0.0231) were less likely to have dyslipidemia. Decision tree analysis showed that enhancing physical activity could effectively reduce the rate of dyslipidemia among people with overweight or obesity. Conclusions 4Overweight and obesity are rapidly growing threats in China. Regular physical activity could positively affect dyslipidemia and produce desirable health status. This will be beneficial evidence for educating those who do not or cannot perform regular and substantial physical activities.

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“…Within teaching, resistance to change is one of the most difficult problems at universities in Brazil. Barriers to the replacement of animal procedures could be addressed by focusing on humane education, using a novel tool: a decision tree (DT) approach (Bones et al, 2016). The DT approach discusses barriers that hinder replacement and helps to address the main obstacles.…”

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confidence: 99%