The use of a diazonium salt for the determination of glutamic-oxalacetic transaminase in serum

Babson, Arthur L.; Shapiro, Paul O.; Williams, Prunella A. Read; Phillips, George E.

doi:10.1016/0009-8981(62)90010-4

Cited by 140 publications

(25 citation statements)

References 11 publications

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“…This concentration (approximately 10 mg. per 100 ml. serum) and the associated severe hypothermia also occurred in rats dying of insulin-induced hypoglyeaemia and in patients dying with hypoglyeaemic shock (Marble, 1952;Williams, 1962;Himwich, 1951;Kedes and Field, 1964). Although it was not possible to prolong life indefinitely, significant survival was achieved by glucose infusion.…”

Section: Glucosementioning

confidence: 99%

Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour

Killington¹,

Williams²,

Ratcliffe³

et al. 1971

Br J Cancer

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SUMMARY.-A possible basis for the differences in malignancy between three closely related sublines of the WBP1 ascites tumour of the rat has been studied by examining the biochemical changes in rat sera during tumour growth in vivo. Death appeared to be due to hypoglycaemia and the ability to induce this condition correlated with the differences in malignancy between the sublines; WBP1 (X) and WBP1 (V), the more malignant sublines, inducing hypoglycaemia earlier and more rapidly than the least malignant subline WBP1 (A). (Sylve'n and Holmberg, 1965; Nakahara, 1968) and that tumour's of differing malignancy might differ in their toxicities has been suggested (Sylve'n and Holmberg, 1965).Biochemical changes observed in serum, urine and the body fluids, associated with various diseases, often indicate the nature of the pathological change and the organ involved. In human medicine, automated analysis (Whitehead, 1968) of approximately 14 selected substances in serum detects some aspect of many diseases and additional serum components can be determined subsequently if necessary. This paper describes attempts to determine the basis of the different malignancies of the WBPI sublines by examining rat sera in this manner during the growth of WBP I (A), WBPI (V) and WBP I (X), the last being an even more malignant subline derived by intraperitoneal passage of WBPI (V) (see Materials and Methods). By following the biochemical changes from tumour inoculation until death it was hoped that the primary changes initiated by the tumour might be differentiated from secondary deterioration effects in the terminal stages of the disease.

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Section: Glucosementioning

confidence: 99%

Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour

Killington¹,

Williams²,

Ratcliffe³

et al. 1971

Br J Cancer

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“…Consequently, the averaged PL/TG ratio was 4.6. Increased values of serum glutamic-oxaloacetic transaminase (Wroblewski 1958, Babson et al 1962 were noticed only in this case among 16 intoxication cases. In 4 moderately affected cases, the PL/TG ratio was an average of 4.9 with range from 4.1 to 5.8.…”

Section: Resultsmentioning

confidence: 57%

Lipid Changes in Serum Following Drug Shock and Intoxication

Murata

Nakazawa

1971

Tohoku J. Exp. Med.

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“…In addition to the dominant lethal, reproductive efficiency, teratology, and pathology examinations described previously for the FO rats, blood for clinical chemistry and hematology was drawn by heart puncture Downloaded by [Purdue University] at 22:47 12 April 2015 from ten males and ten females of each group of animals at terminal sacrifice. Clinical chemistry tests included serum glucose (Hoffman, 1937), blood urea nitrogen (Skeggs, 1957;Marsh et al, 1957), and serum glutamic-oxaloacetic transaminase (SGOT) activity (Babson et al, 1962). Serum sodium and potassium concentrations were determined with a flame photometer, model 343, Instrument Laboratory, Inc.…”

Section: Methodsmentioning

confidence: 99%

Intermediate‐duration toxicity study of patulin in rats

Dailey

Brouwer

Blaschka

et al. 1977

Journal of Toxicology and Environmental Health

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The toxicity of patulin was studied in two generations of Sprague-Dawley rats over a period of approximately 10 months. Patulin in 1 mM citrate buffer was administered by gavage to FO generation rats at a dose level of 0, 1.5, 7.5, or 15.0 mg/kg a body weight five times a week for 10-14 wk; females were treated seven times a week during pregnancy. High mortality and insufficient progeny in the groups given 7.5 and 15.0 mg/kg made it impossible to continue those two regimens into the second generation. The study was continued for 20-23 wk with F1A generation animals given 1.5 mg/kg and controls. The only lesion found at necropsy that could be attributed to patulin administration was gaseous distention of the gastrointestinal tract, which was probably the result of the antibiotic effect of this mycotoxin on the normal intestinal flora. A decreased weight gain in male rats of the FO generation was dose-related. An impairment in growth rates of F1A and F2A progeny of both sexes was statistically significant at the 1.5 mg/kg dose level. Fetuses taken from patulin-treated females on day 20 of pregnancy were noticeably smaller than controls fetuses and the difference was significant for F2A males. No other teratological abnormalities related to patulin dosing at the 1.5 mg/kg level were observed consistently in either F1A or F2A fetuses. Patulin did not appear to produce dominant lethal effects at dose levels up to 15.0 mg/kg when given by gavage to the males five times a week for 10 or 11 wk.

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The use of a diazonium salt for the determination of glutamic-oxalacetic transaminase in serum

Cited by 140 publications

References 11 publications

Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour

Hypoglycaemia and Malignancy Differences of Closely Related Sublines of a Rat Tumour

Lipid Changes in Serum Following Drug Shock and Intoxication

Intermediate‐duration toxicity study of patulin in rats

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