The Use of a Fibrin Glue with a Low Concentration of Thrombin Decreases Seroma Formation in Postbariatric Patients Undergoing Circular Abdominoplasty

Abstract

The use of a fibrin glue with a low concentration of thrombin could be useful during wound closure and may decrease seroma formation in postbariatric patients undergoing lipo-abdominoplasty.

Seromas as a Complication of Surgical Treatment of Incisional Hernias of Anterior Abdominal Wall Using Mesh Implants: Current State of the Problem

“…Они встречаются в широких пределах от 0,8 % до 60% [7,8,9,10]. Образование хронических сером при onlay расположении сетки связано с персистирующим асептическим воспалением и лимфореей, вследствие постоянной травмати-зации тканей подкожной клетчатки сетчатым имплантом, что приводит к удлинению сроков пребывания пациентов в стационаре, так как зачастую требуется выполнение многократных пункций жидкостных скоплений [11].…”

Effect of Tissue Adhesives on Seroma Incidence After Abdominoplasty: A Systematic Review and Meta-Analysis

“…For 3 of the 5 RCTs, the methods for random-sequence generation and allocation concealment were not described or the description was unclear. [28][29][30] Therefore, these studies were considered to have a high risk or unclear risk of bias. Although randomization was noted in the reports of the other 2 RCTs, the type of randomization was not described.…”

“…Therefore, all 5 RCTs were classified as inadequate because of the high risk of bias. [27][28][29][30][31] To assess the risk of bias for incomplete outcome data, we evaluated the incidence of seroma formation after abdominoplasty (ie, the primary outcome measure) for each of the 5 RCTs. We also determined whether an intention-to-treat (ITT) analysis was performed in each study and whether missing data were described and addressed.…”

“…Although it was not possible to evaluate the protocol from which each RCT was derived, we concluded that all 5 RCTs carried a low risk of selective-reporting bias because each trial adequately addressed primary and secondary outcome measures. [27][28][29][30][31] Three of the 5 RCT reports did not include statements of approval by an ethics board. 28,29,31 However, all 5 included descriptions of any conflicts of interest and clear explanations of inclusion and exclusion criteria.…”

“…However, authors who subsequently applied fibrin glue and other TAs in abdominoplasty did not report consistently favorable results. 27,[29][30][31][32] The existing literature regarding TAs in abdominoplasty is limited to small studies and the findings of single institutions. To our knowledge, a systematic review of these studies has not been published.…”