The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy

Akhavan, Omid; Ghaderi, Elham; Aghayee, Samira; Fereydooni, Yasamin; Talebi, Ali

doi:10.1039/c2jm31396k

Cited by 401 publications

(249 citation statements)

References 57 publications

Supporting

Mentioning

240

Contrasting

Unclassified

Order By: Relevance

“…Aer the addition of dopamine, the color of the GO suspension changed from light brown to black, implying the reduction of GO to graphene. 56,57 Furthermore, the obtained GC samples demonstrated excellent aqueous stability. No sediment was observed even aer the GC dispersion was stored for more than three months.…”

Section: This Journal Is ª the Royal Society Of Chemistry 2013mentioning

confidence: 86%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

View full text Add to dashboard Cite

Multifunctional integration is an inherent characteristic for biological materials with multiscale structures. Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect). Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anticorrosion, and remarkable mechanical properties underwater. Multifunctional integration is an inherent characteristic for biological materials with multiscale structures.Learning from nature is an effective approach for scientists and engineers to construct multifunctional materials. In nature, mollusks (abalone), mussels, and the lotus have evolved different and optimized solutions to survive. Here, bio-inspired multifunctional graphene composite paper was fabricated in situ through the fusion of the different biological solutions from nacre (brick-and-mortar structure), mussel adhesive protein (adhesive property and reducing character), and the lotus leaf (self-cleaning effect).Owing to the special properties (self-polymerization, reduction, and adhesion), dopamine could be simultaneously used as a reducing agent for graphene oxide and as an adhesive, similar to the mortar in nacre, to crosslink the adjacent graphene. The resultant nacre-like graphene paper exhibited stable superhydrophobicity, self-cleaning, anti-corrosion, and remarkable mechanical properties underwater.

show abstract

Section: This Journal Is ª the Royal Society Of Chemistry 2013mentioning

confidence: 86%

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

et al. 2013

View full text Add to dashboard Cite

show abstract

“…16, 17 Wang et al 18 have suggested that dose-and time-dependent cytotoxicity of GO, which can enter the cytoplasm and nucleus, decreases cell adhesion and induces apoptosis. Recently, Akhavan et al 19 reported the biomedical application of biocompatible glucose-reduced GO in photothermal cancer therapy (without any PEGylation). In addition, other research groups have investigated the application of nanoscale reduced GO-quantum dot nanocomposites in magnetically targeted drug delivery, photothermal therapy, and fluorescence, photoacoustic, and magnetic resonance imaging.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa

Gurunathan¹,

Han²,

Dayem³

et al. 2012

IJN

739

511

View full text Add to dashboard Cite

Background: Graphene holds great promise for potential use in next-generation electronic and photonic devices due to its unique high carrier mobility, good optical transparency, large surface area, and biocompatibility. The aim of this study was to investigate the antibacterial effects of graphene oxide (GO) and reduced graphene oxide (rGO) in Pseudomonas aeruginosa. In this work, we used a novel reducing agent, betamercaptoethanol (BME), for synthesis of graphene to avoid the use of toxic materials. To uncover the impacts of GO and rGO on human health, the antibacterial activity of two types of graphene-based material toward a bacterial model P. aeruginosa was studied and compared. Methods: The synthesized GO and rGO was characterized by ultraviolet-visible absorption spectroscopy, particle-size analyzer, X-ray diffraction, scanning electron microscopy and Raman spectroscopy. Further, to explain the antimicrobial activity of graphene oxide and reduced graphene oxide, we employed various assays, such as cell growth, cell viability, reactive oxygen species generation, and DNA fragmentation. Results: Ultraviolet-visible spectra of the samples confirmed the transition of GO into graphene. Dynamic light-scattering analyses showed the average size among the two types of graphene materials. X-ray diffraction data validated the structure of graphene sheets, and high-resolution scanning electron microscopy was employed to investigate the morphologies of prepared graphene. Raman spectroscopy data indicated the removal of oxygen-containing functional groups from the surface of GO and the formation of graphene. The exposure of cells to GO and rGO induced the production of superoxide radical anion and loss of cell viability. Results suggest that the antibacterial activities are contributed to by loss of cell viability, induced oxidative stress, and DNA fragmentation. Conclusion:The antibacterial activities of GO and rGO against P. aeruginosa were compared. The loss of P. aeruginosa viability increased in a dose-and time-dependent manner. Exposure to GO and rGO induced significant production of superoxide radical anion compared to control. GO and rGO showed dose-dependent antibacterial activity against P. aeruginosa cells through the generation of reactive oxygen species, leading to cell death, which was further confirmed through resulting nuclear fragmentation. The data presented here are novel in that they prove that GO and rGO are effective bactericidal agents against P. aeruginosa, which would be used as a future antibacterial agent.

show abstract

“…The resulting rGO powder was biocompatible and highly dispersible in water. Likewise, Akhavan et al [40] found that glucose increases its power to reduce GO in the presence of an iron catalyst under neutral condition.…”

Section: Saccharidesmentioning

confidence: 99%

Green Routes for Graphene Oxide Reduction and Self- Assembled Graphene Oxide Micro- and Nanostructures Production

Ortega-Amaya¹,

Matsumoto²,

Díaz-Torres³

et al. 2017

Graphene Materials - Structure, Properties and Modifications

View full text Add to dashboard Cite

Graphene-derived materials are currently studied because of their actual and projected applications. Among them, graphene oxide (GO) promises for outstanding applications as it can be prepared at large scale by simple, scalable, and low-cost techniques. The existent chemical methods based on the graphite exfoliation (phase solution and Hummers based) produce highly functionalized graphene, i.e., GO-like materials that converts into reduced GO (rGO) after a reduction treatment. The present work presents the current scenario on the GO green reduction methods, on the development of hierarchical carbon-based structures by the self-assembly of GO sheets at interfaces, and on rGObased hybrid nanocomposites. It is worth noting that, to date, the production and application of graphene-related materials are the fastest-growing research areas.

show abstract

The use of a glucose-reduced graphene oxide suspension for photothermal cancer therapy

Cited by 401 publications

References 57 publications

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Fusion of nacre, mussel, and lotus leaf: bio-inspired graphene composite paper with multifunctional integration

Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa

Green Routes for Graphene Oxide Reduction and Self- Assembled Graphene Oxide Micro- and Nanostructures Production

Contact Info

Product

Resources

About